Improve heart function to improve heart failure outcomes: the disease‐modifying effects of spironolactone
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Heart Failure"
DOI: 10.1002/ejhf.2757
Abstract: This article refers to ‘Spironolactone effect on cardiac structure and function of patients with heart failure and preserved ejection fraction: a pooled analysis of three randomized trials’ by J.P. Ferreira et al. , published in… read more here.
Keywords: heart function; heart failure; improve heart; heart ... See more keywords
Journey of the Right Heart Following Left Ventricular Assist Device Implantation
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cardiac Failure"
DOI: 10.1016/j.cardfail.2020.09.401
Abstract: Introduction Right heart function impacts outcomes in left ventricular assist devices (LVADs) but a comprehensive exploration of changes in right heart function over time and its effects on outcomes has not been fully elucidated. We… read more here.
Keywords: right heart; time; post implant; heart ... See more keywords
Heme oxygenase-1 prevents heart against myocardial infarction by attenuating ischemic injury-induced cardiomyocytes senescence
Sign Up to like & getrecommendations! Published in 2019 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2018.11.056
Abstract: Background Cellular senescence is a stable cell-cycle arrest induced by telomere shortening and various types of cellular stress including oxidative stress, oncogene activation, DNA damage etc. Heme oxygenase-1 (HO-1) is an inducible stress-response protein that… read more here.
Keywords: cardiomyocyte senescence; heart; heart function; senescence ... See more keywords
Blocking CCL5-CXCL4 heteromerization preserves heart function after myocardial infarction by attenuating leukocyte recruitment and NETosis
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-29026-0
Abstract: Myocardial infarction (MI) is a major cause of death in Western countries and finding new strategies for its prevention and treatment is thus of high priority. In a previous study, we have demonstrated a pathophysiologic… read more here.
Keywords: treatment; heart function; myocardial infarction; infarction ... See more keywords
Effects of the MitraClip on right heart function and tricuspid valve regurgitation
Sign Up to like & getrecommendations! Published in 2020 at "European Heart Journal"
DOI: 10.1093/ehjci/ehaa946.0002
Abstract: The MitraClip has been established as a therapeutic option for patients with symptomatic mitral regurgitation (MR) and increased risk of Surgery. MR is often combined with a decrease in right heart function due to the… read more here.
Keywords: regurgitation; heart; heart function; right heart ... See more keywords
Trimetazidine affects MCU expression to restore ischemic heart function via ROS/NFκB pathway inhibition.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of cardiovascular pharmacology"
DOI: 10.1097/fjc.0000000000001434
Abstract: ABSTRACT Studies have demonstrated the roles of trimetazidine beyond being an antianginal agent in ischemic heart disease (IHD) treatment associated with mechanisms of calcium regulation. Our recent studies revealed that mitochondrial calcium uniporter (MCU, the… read more here.
Keywords: calcium; inhibition; trimetazidine; heart function ... See more keywords
Echinacoside inhibited cardiomyocyte pyroptosis and improved heart function of HF rats induced by isoproterenol via suppressing NADPH/ROS/ER stress
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17564
Abstract: Prevalence of heart failure (HF) continues to rise over time and is a global difficult problem; new drug targets are urgently needed. In recent years, pyroptosis is confirmed to promote cardiac remodelling and HF. Echinacoside… read more here.
Keywords: improved heart; pyroptosis; heart function; cardiomyocyte pyroptosis ... See more keywords
Impact of Different Serum Potassium Levels on Postresuscitation Heart Function and Hemodynamics in Patients with Nontraumatic Out-of-Hospital Cardiac Arrest
Sign Up to like & getrecommendations! Published in 2018 at "Bioinorganic Chemistry and Applications"
DOI: 10.1155/2018/5825929
Abstract: Background Sustained return of spontaneous circulation (ROSC) can be initially established in patients with out-of-hospital cardiac arrest (OHCA); however, the early postresuscitation hemodynamics can still be impaired by high levels of serum potassium (hyperkalemia). The… read more here.
Keywords: potassium; heart function; hemodynamics; postresuscitation heart ... See more keywords
Contractile Force of Transplanted Cardiomyocytes Actively Supports Heart Function After Injury
Sign Up to like & getrecommendations! Published in 2022 at "Circulation"
DOI: 10.1161/circulationaha.122.060124
Abstract: Background: Transplantation of pluripotent stem cell–derived cardiomyocytes represents a promising therapeutic strategy for cardiac regeneration, and the first clinical studies in patients with heart failure have commenced. Yet, little is known about the mechanism of… read more here.
Keywords: function; heart function; heart; transplanted cardiomyocytes ... See more keywords
Critical role of Znhit1 for postnatal heart function and vacuolar cardiomyopathy
Sign Up to like & getrecommendations! Published in 2022 at "JCI Insight"
DOI: 10.1172/jci.insight.148752
Abstract: Ca2+ is critical for cardiac electrical conduction and contractility, and aberrant Ca2+ homeostasis causes arrhythmia and heart failure. Chromatin remodeling modulates gene expression involved in cardiac sarcomere assembly and postnatal heart function. However, the chromatin-remodeling… read more here.
Keywords: znhit1; postnatal heart; heart function; vacuolar cardiomyopathy ... See more keywords
Improvement of Heart Function After Transplantation of Encapsulated Stem Cells Induced with miR-1/Myocd in Myocardial Infarction Model of Rat
Sign Up to like & getrecommendations! Published in 2021 at "Cell Transplantation"
DOI: 10.1177/09636897211048786
Abstract: Cardiovascular disease is one of the most common causes of death worldwide. Mesenchymal stem cells (MSCs) are one of the most common sources in cell-based therapies in heart regeneration. There are several methods to differentiate… read more here.
Keywords: heart; heart function; model; mir myocd ... See more keywords