Biodegradable nanofibrous temperature-responsive gelling microspheres for heart regeneration.
Sign Up to like & getrecommendations! Published in 2020 at "Advanced functional materials"
DOI: 10.1002/adfm.202000776
Abstract: Myocardial infarction (heart attack) is the number one killer of heart patients. Existing treatments for heart attack do not address the underlying problem of cardiomyocyte (CM) loss and cannot regenerate the myocardium. Introducing exogenous cardiac… read more here.
Keywords: heart; biodegradable nanofibrous; gelling microspheres; heart regeneration ... See more keywords
A Genetic Cardiomyocyte Ablation Model for the Study of Heart Regeneration in Zebrafish.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0668-1_7
Abstract: Adult zebrafish possess an elevated cardiac regenerative capacity as compared with adult mammals. In the past two decades, zebrafish have provided a key model system for studying the cellular and molecular mechanisms of innate heart regeneration.… read more here.
Keywords: heart; genetic cardiomyocyte; ablation; model ... See more keywords
Mechanisms of Neonatal Heart Regeneration
Sign Up to like & getrecommendations! Published in 2020 at "Current Cardiology Reports"
DOI: 10.1007/s11886-020-01282-5
Abstract: Purpose of Review This review provides an overview of the molecular mechanisms underpinning the cardiac regenerative capacity during the neonatal period and the potential targets for developing novel therapies to restore myocardial loss. Recent Findings… read more here.
Keywords: cardiology; regeneration; neonatal heart; mechanisms neonatal ... See more keywords
A Unique Collateral Artery Development Program Promotes Neonatal Heart Regeneration
Sign Up to like & getrecommendations! Published in 2019 at "Cell"
DOI: 10.1016/j.cell.2018.12.023
Abstract: Collateral arteries are an uncommon vessel subtype that can provide alternate blood flow to preserve tissue following vascular occlusion. Some patients with heart disease develop collateral coronary arteries, and this correlates with increased survival. However,… read more here.
Keywords: heart; artery; neonatal heart; collateral artery ... See more keywords
PDGFR-β Signaling Regulates Cardiomyocyte Proliferation and Myocardial Regeneration.
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.06.065
Abstract: Platelet-derived growth factor receptor (PDGFR) signaling is involved in proliferation and survival in a wide array of cell types. The role of PDGFR signaling in heart regeneration is still unknown. We find that PDGFR-β signaling… read more here.
Keywords: heart regeneration; regeneration; pdgfr signaling; cardiomyocyte proliferation ... See more keywords
Signals for cardiomyocyte proliferation during zebrafish heart regeneration.
Sign Up to like & getrecommendations! Published in 2020 at "Current opinion in physiology"
DOI: 10.1016/j.cophys.2020.02.002
Abstract: The common laboratory zebrafish can regenerate functional cardiac muscle after cataclysmic damage or loss, by activating programs that direct the division of spared cardiomyocytes. Heart regeneration is not a linear series of molecular steps and… read more here.
Keywords: proliferation zebrafish; heart regeneration; heart; cardiomyocyte proliferation ... See more keywords
Modulation of TNFα Activity by the microRNA Let-7 Coordinates Zebrafish Heart Regeneration
Sign Up to like & getrecommendations! Published in 2019 at "iScience"
DOI: 10.1016/j.isci.2019.04.009
Abstract: Summary The adult zebrafish is capable of regenerating heart muscle, resolving collagen tissue, and fully restoring heart function throughout its life. In this study, we show that the highly upregulated, epicardium-enriched microRNA let-7i functions in… read more here.
Keywords: heart; tnf; let; heart regeneration ... See more keywords
Toward the Goal of Human Heart Regeneration.
Sign Up to like & getrecommendations! Published in 2020 at "Cell stem cell"
DOI: 10.1016/j.stem.2019.12.004
Abstract: Heart regeneration, a relatively new field of biology, is one of the most active and controversial areas of biomedical research. The potential impact of successful human heart regeneration therapeutics cannot be overstated, given the magnitude… read more here.
Keywords: goal; human heart; heart; biology ... See more keywords
The FGF-AKT pathway is necessary for cardiomyocyte survival for heart regeneration in zebrafish.
Sign Up to like & getrecommendations! Published in 2021 at "Developmental biology"
DOI: 10.1016/j.ydbio.2020.12.019
Abstract: Zebrafish have a remarkable ability to regenerate the myocardium after injury by proliferation of pre-existing cardiomyocytes. Fibroblast growth factor (FGF) signaling is known to play a critical role in zebrafish heart regeneration through promotion of… read more here.
Keywords: heart; fgf signaling; injury; heart regeneration ... See more keywords
Nrf1 promotes heart regeneration and repair by regulating proteostasis and redox balance
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-25653-w
Abstract: Following injury, cells in regenerative tissues have the ability to regrow. The mechanisms whereby regenerating cells adapt to injury-induced stress conditions and activate the regenerative program remain to be defined. Here, using the mammalian neonatal… read more here.
Keywords: redox balance; heart regeneration; heart; nrf1 ... See more keywords
Cardiac injury modulates critical components of prostaglandin E2 signaling during zebrafish heart regeneration
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-59868-6
Abstract: The inability to effectively stimulate cardiomyocyte proliferation remains a principle barrier to regeneration in the adult human heart. A tightly regulated, acute inflammatory response mediated by a range of cell types is required to initiate… read more here.
Keywords: heart; regeneration; proliferation; cardiac injury ... See more keywords