Tapered Pillar Design for High‐Precision Force Readout in Miniaturized Engineered Heart Tissues From Human Pluripotent Stem Cells
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202501664
Abstract: Engineered heart tissues (EHTs) formed around flexible pillars are used to measure the contraction force of myocytes. When based on cardiac cells derived from human induced pluripotent stem cells (hiPSCs), EHTs capture human cardiac physiology… read more here.
Keywords: force; engineered heart; pluripotent stem; stem cells ... See more keywords
Engineered heart tissues formed with cardiac progenitors and differentiated cardiomyocytes exhibit similar physiologic properties at differentiation-matched timepoints
Sign Up to like & getrecommendations! Published in 2025 at "Biofabrication"
DOI: 10.1088/1758-5090/ae1259
Abstract: Congenital heart diseases, including single ventricle heart defects such as hypoplastic left and right heart syndromes, remain a leading cause of neonatal death and long-term morbidity. Regenerative medicine approaches hold great therapeutic promise for treating… read more here.
Keywords: heart; engineered heart; cell; tissues formed ... See more keywords
Dynamic Patterns of N6-Methyladenosine Profiles of Messenger RNA Correlated with the Cardiomyocyte Regenerability during the Early Heart Development in Mice
Sign Up to like & getrecommendations! Published in 2021 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2021/5537804
Abstract: N6-Methyladenosine (m6A) plays important roles in regulating mRNA processing. Despite rapid progress in this field, little is known about the role and mechanism of m6A modification in myocardial development and cardiomyocyte regeneration. Existing studies have… read more here.
Keywords: day old; heart; heart tissues; mice ... See more keywords
Neurogenic differentiation 2 promotes inflammatory activation of macrophages in doxorubicin-induced myocarditis via regulating protein kinase D
Sign Up to like & getrecommendations! Published in 2025 at "BMC Cardiovascular Disorders"
DOI: 10.1186/s12872-025-04626-7
Abstract: Although it has been established that protein kinase D (PKD) plays a crucial role in various diseases, its precise role in myocarditis remains elusive. To investigate PKD’s involvement in myocarditis, we established a mouse model… read more here.
Keywords: protein kinase; induced myocarditis; heart tissues; pkd ... See more keywords
Deletion of MAPL ameliorates septic cardiomyopathy by mitigating mitochondrial dysfunction
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Translational Medicine"
DOI: 10.1186/s12967-024-05836-x
Abstract: Mitochondrial dysfunction is a critical factor in the pathogenesis of septic cardiomyopathy (SCM). Mitochondrial anchored protein ligase (MAPL), a small ubiquitin-like modifier (SUMO) E3 ligase, plays a significant role in mitochondrial function. However, the role… read more here.
Keywords: mapl; dysfunction; mitochondrial dysfunction; heart tissues ... See more keywords
Contractility analysis of human engineered 3D heart tissues by an automatic tracking technique using a standalone application
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0266834
Abstract: The use of Engineered Heart Tissues (EHT) as in vitro model for disease modeling and drug screening has increased, as they provide important insight into the genetic mechanisms, cardiac toxicity or drug responses. Consequently, this… read more here.
Keywords: heart tissues; standalone application; engineered heart; analysis ... See more keywords
Curcumin mediated attenuation of carbofuran induced toxicity in the heart of Wistar rats.
Sign Up to like & getrecommendations! Published in 2017 at "Cellular and molecular biology"
DOI: 10.14715/cmb/2017.63.6.3
Abstract: Carbofuran is used to improve the agricultural productivity as well as to protect the house hold and industrial products, but due to accumulation in the biological system, it causes serious side effects in many non-targets… read more here.
Keywords: heart; carbofuran; heart tissues; attenuation ... See more keywords
A New Versatile Platform for Assessment of Improved Cardiac Performance in Human-Engineered Heart Tissues
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Personalized Medicine"
DOI: 10.3390/jpm12020214
Abstract: Cardiomyocytes derived from human pluripotent stem cells (hPSC-CMs) hold a great potential as human in vitro models for studying heart disease and for drug safety screening. Nevertheless, their associated immaturity relative to the adult myocardium… read more here.
Keywords: heart tissues; platform; new versatile; heart ... See more keywords