Development of live attenuated bacterial vaccines targeting Escherichia coli heat-labile and heat-stable enterotoxins.
Sign Up to like & getrecommendations! Published in 2017 at "Veterinary microbiology"
DOI: 10.1016/j.vetmic.2017.04.010
Abstract: Enterotoxigenic Escherichia coli (ETEC), defined by the production of heat labile (LT) and/or heat stable (ST) toxins, are major causes of diarrhea in animals, children in developing countries and to travelers. No broadly protective ETEC… read more here.
Keywords: heat stable; heat labile; escherichia coli; live attenuated ... See more keywords
Construction of an inactivated typhoid vaccine candidate expressing Escherichia coli heat‐labile enterotoxin B subunit and evaluation of its immunogenicity in a murine model
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Medical Microbiology"
DOI: 10.1099/jmm.0.000543
Abstract: Purpose. Typhoid fever caused by Salmonella enterica serovar Typhi has contributed to the global public health burden, particularly in developing countries. In this study, an S. Typhi ghost was developed and its capacity as a… read more here.
Keywords: heat labile; ltb; vaccine candidate; coli heat ... See more keywords
Immunogenicity of recombinant Lactobacillus casei‐expressing F4 (K88) fimbrial adhesin FaeG in conjunction with a heat‐labile enterotoxin A (LTAK63) and heat‐labile enterotoxin B (LTB) of enterotoxigenic Escherichia coli as an oral adjuvant in mice
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Applied Microbiology"
DOI: 10.1111/jam.13352
Abstract: The aims of this study were to develop an effective oral vaccine against enterotoxigenic Escherichia coli (ETEC) infection and to design new and more versatile mucosal adjuvants. read more here.
Keywords: heat labile; escherichia coli; labile enterotoxin; enterotoxigenic escherichia ... See more keywords
Evaluating the efficacy of non-thermal microbial load reduction treatments of heat labile food components for in vitro fermentation experiments
Sign Up to like & getrecommendations! Published in 2023 at "PLOS ONE"
DOI: 10.1371/journal.pone.0283287
Abstract: Increasingly, in vitro simulated colon fermentations are being used as a pre-clinical step to assess the impacts of foods and drugs on the gut microbiota in a cost-effective manner. One challenge in such systems is… read more here.
Keywords: food; food components; heat; fermentation ... See more keywords
Heat-Labile Enterotoxin-Induced PERK-CHOP Pathway Activation Causes Intestinal Epithelial Cell Apoptosis
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2017.00244
Abstract: Enterotoxigenic Escherichia coli (ETEC) is a leading cause of diarrhea among children and travelers in developing countries, and heat-labile enterotoxin (LT) is one of the most important virulence factors. The pathogenesis of and virulence factors… read more here.
Keywords: intestinal epithelial; epithelial cell; apoptosis; heat labile ... See more keywords
Review of Newly Identified Functions Associated With the Heat-Labile Toxin of Enterotoxigenic Escherichia coli
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2019.00292
Abstract: Heat-labile toxin (LT) is a well-characterized powerful enterotoxin produced by enterotoxigenic Escherichia coli (ETEC). This toxin is known to contribute to diarrhea in young children in developing countries, international travelers, as well as many different… read more here.
Keywords: escherichia coli; toxin; labile toxin; heat labile ... See more keywords
Production of monoclonal antibody of heat-labile toxin A subunit to identify enterotoxigenic Escherichia coli by epitope mapping using synthetic peptides
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1152910
Abstract: Background Enterotoxigenic Escherichia coli (ETEC) is a major cause of diarrhea through two enterotoxins, a heat-labile toxin and a heat-stable toxin. These toxins alter the cellular signaling pathways, ultimately triggering an increase in chloride secretion… read more here.
Keywords: synthetic peptides; toxin; enterotoxigenic escherichia; heat ... See more keywords
Both LTA and LTB Subunits Are Equally Important to Heat-Labile Enterotoxin (LT)-Enhanced Bacterial Adherence
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DOI: 10.3390/ijms24021245
Abstract: There is increasing evidence indicating that the production of heat-labile enterotoxin (LT) enhances bacterial adherence within in vitro and in vivo models. However, which subunit plays the main role, and the precise regulatory mechanisms remain… read more here.
Keywords: adherence; bacterial adherence; enhanced bacterial; subunit ... See more keywords
Dendritic Cell-Mediated Mechanisms Triggered by LT-IIa-B5, a Mucosal Adjuvant Derived from a Type II Heat-Labile Enterotoxin of Escherichia coli.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of microbiology and biotechnology"
DOI: 10.4014/jmb.1611.11072
Abstract: Mucosal tissues are the initial site through which most pathogens invade. As such, vaccines and adjuvants that modulate mucosal immune functions have emerged as important agents for disease prevention. Herein, we investigated the immunomodulatory mechanisms… read more here.
Keywords: mucosal adjuvant; escherichia coli; mucosal; heat labile ... See more keywords
Expression of Heat-labile Enterotoxin of Escherichia coli in Biolistic Transformed Hairy Roots of Daucus carota L
Sign Up to like & getrecommendations! Published in 2019 at "Polymer Journal"
DOI: 10.5530/pj.2019.11.x
Abstract: Production of antigens and antibodies in plant provide a potential approach for the development of vaccines for oral delivery.1 Traditional vaccines are facing challenges like storage, distribution and administration but recently their safety and effectiveness… read more here.
Keywords: expression heat; hairy roots; escherichia coli; enterotoxin escherichia ... See more keywords