A new congenital multicore titinopathy associated with fast myosin heavy chain deficiency
Sign Up to like & getrecommendations! Published in 2020 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.51031
Abstract: Congenital titinopathies are myopathies with variable phenotypes and inheritance modes. Here, we fully characterized, using an integrated approach (deep phenotyping, muscle morphology, mRNA and protein evaluation in muscle biopsies), two siblings with congenital multicore myopathy… read more here.
Keywords: titinopathy; heavy chain; congenital multicore; myosin heavy ... See more keywords
Simple plant‐based production and purification of the assembled human ferritin heavy chain as a nanocarrier for tumor‐targeted drug delivery and bioimaging in cancer therapy
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.28312
Abstract: Nanoparticles are used as carriers for the delivery of drugs and imaging agents. Proteins are safer than synthetic nanocarriers due to their greater biocompatibility and the absence of toxic degradation products. In this context, ferritin… read more here.
Keywords: human ferritin; heavy chain; production; delivery ... See more keywords
Investigation of the free heavy chain homodimers of a monoclonal antibody
Sign Up to like & getrecommendations! Published in 2018 at "Biotechnology Progress"
DOI: 10.1002/btpr.2611
Abstract: Monoclonal antibodies (mAbs) are composed of two heavy chain (HC) and two light chain (LC) polypeptides. The proper folding and assembly of HC and LC is critical for antibody production. Current dogma indicates that the… read more here.
Keywords: chain; heavy chain; antibody; level free ... See more keywords
Analytical characterization of broadly neutralizing antibody CAP256LS heavy chain clipping during manufacturing development
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology Progress"
DOI: 10.1002/btpr.3296
Abstract: Broadly neutralizing antibody (bNAb) CAP256‐VRC26.25 (abbreviated CAP256LS), a human IgGI monoclonal antibody targeting the V1V2 site of the HIV‐1 envelope, has demonstrated high therapeutic potential as a broadly neutralizing monoclonal antibody against HIV‐1. During the… read more here.
Keywords: heavy chain; analytical characterization; broadly neutralizing; development ... See more keywords
Inter‐alpha‐trypsin inhibitor heavy chain 4: A serologic marker relating to disease risk, activity, and treatment outcomes of rheumatoid arthritis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24231
Abstract: Inter‐alpha‐trypsin inhibitor heavy chain 4 (ITIH4) regulates immunity and inflammation, but its clinical role in rheumatoid arthritis (RA) patients remains unclear. Hence, this study was conducted to explore the association of circulating ITIH4 with disease… read more here.
Keywords: heavy chain; inter alpha; alpha trypsin; trypsin inhibitor ... See more keywords
Longitudinal change of serum inter‐alpha‐trypsin inhibitor heavy chain H4, and its correlation with inflammation, multiorgan injury, and death risk in sepsis
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24834
Abstract: Inter‐alpha‐trypsin inhibitor heavy chain H4 (ITIH4) inhibits infection‐induced inflammation and multiorgan injury through several methods. The present study aimed to estimate the association of serum ITIH4 with inflammatory cytokines, multiorgan injury, and death risk in… read more here.
Keywords: heavy chain; inter alpha; alpha trypsin; trypsin inhibitor ... See more keywords
Electroinduced Extraction of Human Ferritin Heavy Chain Expressed in Hansenula polymorpha
Sign Up to like & getrecommendations! Published in 2017 at "Applied Biochemistry and Biotechnology"
DOI: 10.1007/s12010-017-2627-9
Abstract: AbstractА protocol for the efficient and selective recovery of human ferritin heavy chain (FTH1) expressed intracellularly in Hansenula polymorpha was developed. It was based on electropermeabilisation and an increase in the cell wall porosity by… read more here.
Keywords: ferritin heavy; heavy chain; human ferritin; polymorpha ... See more keywords
Ferritin heavy chain controls the HIF-driven hypoxic response by activating the asparaginyl hydroxylase FIH.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.03.173
Abstract: Hypoxia-inducible factor 1 (HIF-1) is a key player in cellular response to hypoxia. The stability and transcriptional activity of this protein are oxygen-dependently regulated by the prolyl hydroxylases PHD1-3 and the asparaginyl hydroxylase FIH. Recently,… read more here.
Keywords: ferritin heavy; hif; asparaginyl hydroxylase; heavy chain ... See more keywords
α1-Heavy Chain Deposition Disease With Negative Immunofluorescence Staining on Renal Biopsy
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DOI: 10.1016/j.ekir.2018.09.007
Abstract: Alejandro Best Rocha, Christopher P. Larsen, Paul A. Delyria, Latha Sree Polavaram, Samar M. Said, Robert S. Shibata, Karen L. Rech and Samih H. Nasr Arkana Laboratories, Little Rock, Arkansas, USA; Renal Associates of West… read more here.
Keywords: michigan usa; rapids michigan; heavy chain; pathology ... See more keywords
Systematic engineering of optimized autonomous heavy-chain variable domains.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2021.167241
Abstract: Autonomous heavy-chain variable (VH) domains are the smallest functional antibody fragments, and they possess unique features, including small size and convex paratopes, which provide enhanced targeting of concave epitopes that are difficult to access with… read more here.
Keywords: chain; aggregation; heavy chain; variable domains ... See more keywords
Unravelling the immunopathological mechanisms of heavy chain deposition disease with implications for clinical management.
Sign Up to like & getrecommendations! Published in 2017 at "Kidney international"
DOI: 10.1016/j.kint.2016.09.004
Abstract: Randall-type heavy chain deposition disease (HCDD) is a rare disorder characterized by tissue deposition of a truncated monoclonal immunoglobulin heavy chain lacking the first constant domain. Pathophysiological mechanisms are unclear and management remains to be… read more here.
Keywords: chain; heavy chain; disease; deposition ... See more keywords