Pd-Catalyzed Cascade Intramolecular Heck Cyclization/Dearomatization of Indoles for the Construction of Two All-Carbon Quaternary Centers.
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DOI: 10.1021/acs.orglett.2c03691
Abstract: A facile Pd-catalyzed cascade of intramolecular Heck cyclization/alkylpalladium activated dearomatization of aryl alkyne-tethered indole is described. In this single step two nonadjacent all-carbon quaternary centers, two nitrogen-containing heterocycles, and three C(sp2)-C(sp3) bonds are efficiently furnished.… read more here.
Keywords: intramolecular heck; catalyzed cascade; cascade intramolecular; carbon quaternary ... See more keywords
Radical Aza-Heck Cyclization of Imidates via Energy Transfer, Electron Transfer, and Cobalt Catalysis.
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DOI: 10.1021/acscatal.2c00804
Abstract: A radical aza-Heck cyclization has been developed to afford functionally rich products with four contiguous C-heteroatom bonds. This multi-catalytic strategy provides rapid syntheses of dense, medicinally relevant motifs by enabling the conversion of alcohol-derived imidates… read more here.
Keywords: catalysis; transfer; radical aza; aza heck ... See more keywords