HOTf-Catalyzed Alkyl-Heck-type Reaction
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DOI: 10.1016/j.isci.2018.04.020
Abstract: Summary The Heck reaction, along with other cross-coupling reactions, led to a revolution in organic chemistry. In the last 50 years, metal-catalyzed, photo-induced, or base-mediated Heck and Heck-type reactions have been elegantly developed. Brønsted acid-catalyzed… read more here.
Keywords: heck type; type reaction; heck; hotf catalyzed ... See more keywords
Radical C(sp3)-H Heck-type Reaction of N-Alkoxybenzimidoyl Chlorides with Styrenes to Construct Alkenols.
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DOI: 10.1021/acs.orglett.2c00593
Abstract: We report the first radical C(sp3)-H Heck-type reaction of aliphatic alcohols for selective δ- and ε-alkenol synthesis by photoredox catalysis. N-Alkoxybenzimidoyl chlorides are developed as novel alkoxyl radical precursors with tunable redox potentials. Various alkenols… read more here.
Keywords: alkoxybenzimidoyl chlorides; heck type; sp3 heck; type reaction ... See more keywords
Switchable Decarboxylative Heck-Type Reaction and Oxo-alkylation of Styrenes with N-Hydroxyphthalimide Esters under Photocatalysis.
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DOI: 10.1021/acs.orglett.8b01268
Abstract: The switchable visible-light-mediated decarboxylative Heck-type reaction and oxo-alkylation reaction of N-hydroxyphthalimide esters under photocatalysis were developed. Disubstituted or trisubstituted alkenes were obtained in good yield with high E-selectivity in the presence of Brønsted acid as… read more here.
Keywords: reaction oxo; heck type; decarboxylative heck; oxo alkylation ... See more keywords
Highly Chemo-, Regio- and E/Z-Selective Intermolecular Heck-Type Dearomative [2 + 2 + 1] Spiroannulation of Alkyl Bromoarenes with Internal Alkynes.
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DOI: 10.1021/acs.orglett.9b00099
Abstract: Described herein is a palladium-catalyzed dearomative annulation of alkyl bromoarenes with internal alkynes. Challenges in this spiroannulation include the chemoselectivity among [2 + 2 + 1], [2 + 2 + 2], and [3 + 2]… read more here.
Keywords: heck type; internal alkynes; alkyl bromoarenes; bromoarenes internal ... See more keywords
Radical-Mediated Heck-Type Alkylation: Stereoconvergent Synthesis of Functionalized Polyenes.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b02838
Abstract: The stereospecific synthesis of polyenes is of great synthetic value. Disclosed herein is a new, efficient, stereoconvergent approach for the synthesis of functionalized polyenes via a radical-mediated Heck-type alkylation. The easily accessed Z- and E-mixed… read more here.
Keywords: synthesis functionalized; heck type; radical mediated; functionalized polyenes ... See more keywords