Electroreductive Intramolecular Heck‐Type Cyclization for the Synthesis of Benzofused Oxygenated Heterocycles
Sign Up to like & getrecommendations! Published in 2025 at "European Journal of Organic Chemistry"
DOI: 10.1002/ejoc.202500222
Abstract: Conventional synthetic routes to benzofused oxygenated heterocycles, such as Dihydrobenzofuran, chromane and isochromane derivatives, often involve complex synthetic conditions, high costs, and environmental concerns. The key to addressing this challenge lies in achieving transition‐metal‐free C(sp²)–I… read more here.
Keywords: heck type; cyclization; oxygenated heterocycles; electroreductive intramolecular ... See more keywords
HOTf-Catalyzed Alkyl-Heck-type Reaction
Sign Up to like & getrecommendations! Published in 2018 at "iScience"
DOI: 10.1016/j.isci.2018.04.020
Abstract: Summary The Heck reaction, along with other cross-coupling reactions, led to a revolution in organic chemistry. In the last 50 years, metal-catalyzed, photo-induced, or base-mediated Heck and Heck-type reactions have been elegantly developed. Brønsted acid-catalyzed… read more here.
Keywords: heck type; type reaction; heck; hotf catalyzed ... See more keywords
Radical C(sp3)-H Heck-type Reaction of N-Alkoxybenzimidoyl Chlorides with Styrenes to Construct Alkenols.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c00593
Abstract: We report the first radical C(sp3)-H Heck-type reaction of aliphatic alcohols for selective δ- and ε-alkenol synthesis by photoredox catalysis. N-Alkoxybenzimidoyl chlorides are developed as novel alkoxyl radical precursors with tunable redox potentials. Various alkenols… read more here.
Keywords: alkoxybenzimidoyl chlorides; heck type; sp3 heck; type reaction ... See more keywords
Switchable Decarboxylative Heck-Type Reaction and Oxo-alkylation of Styrenes with N-Hydroxyphthalimide Esters under Photocatalysis.
Sign Up to like & getrecommendations! Published in 2018 at "Organic letters"
DOI: 10.1021/acs.orglett.8b01268
Abstract: The switchable visible-light-mediated decarboxylative Heck-type reaction and oxo-alkylation reaction of N-hydroxyphthalimide esters under photocatalysis were developed. Disubstituted or trisubstituted alkenes were obtained in good yield with high E-selectivity in the presence of Brønsted acid as… read more here.
Keywords: reaction oxo; heck type; decarboxylative heck; oxo alkylation ... See more keywords
Highly Chemo-, Regio- and E/Z-Selective Intermolecular Heck-Type Dearomative [2 + 2 + 1] Spiroannulation of Alkyl Bromoarenes with Internal Alkynes.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b00099
Abstract: Described herein is a palladium-catalyzed dearomative annulation of alkyl bromoarenes with internal alkynes. Challenges in this spiroannulation include the chemoselectivity among [2 + 2 + 1], [2 + 2 + 2], and [3 + 2]… read more here.
Keywords: heck type; internal alkynes; alkyl bromoarenes; bromoarenes internal ... See more keywords
Radical-Mediated Heck-Type Alkylation: Stereoconvergent Synthesis of Functionalized Polyenes.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b02838
Abstract: The stereospecific synthesis of polyenes is of great synthetic value. Disclosed herein is a new, efficient, stereoconvergent approach for the synthesis of functionalized polyenes via a radical-mediated Heck-type alkylation. The easily accessed Z- and E-mixed… read more here.
Keywords: synthesis functionalized; heck type; radical mediated; functionalized polyenes ... See more keywords
Photocatalytic Decarboxylative Heck-Type Postpolymerization Modification of Polyacrylates.
Sign Up to like & getrecommendations! Published in 2025 at "ACS macro letters"
DOI: 10.1021/acsmacrolett.5c00115
Abstract: Postpolymerization modification of commodity polymers has emerged as a powerful strategy for synthesizing functional polymers that are challenging to obtain via direct polymerization. Moreover, it offers opportunities to upcycle existing polymers and enhance their material… read more here.
Keywords: postpolymerization modification; decarboxylative heck; photocatalytic decarboxylative; heck type ... See more keywords
Unified metal-free intermolecular Heck-type sulfonylation, cyanation, amination, amidation of alkenes by thianthrenation
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DOI: 10.1038/s41467-024-44746-w
Abstract: Direct and site-selective C-H functionalization of alkenes under environmentally benign conditions represents a useful and attractive yet challenging transformation to access value-added molecules. Herein, a unified protocol for a variety of intermolecular Heck-type functionalizations of… read more here.
Keywords: metal free; thianthrenation; intermolecular heck; heck type ... See more keywords
Tunable Mono- or 1,1-Double Heck-type Coupling Reaction of Unconjugated Amido-alkenes with Remote Benzylic C(sp3)-H of N-Fluorobenzamides
Sign Up to like & getrecommendations! Published in 2025 at "Organic Chemistry Frontiers"
DOI: 10.1039/d4qo01971g
Abstract: This work described a tunable copper-catalyzed intermolecular oxidative functionalization reaction of unactivated alkenes directed by the remote benzylic free radical of the N-fluoroamides, and the corresponding monoalkylation and 1,1-bialkylation products... read more here.
Keywords: reaction; heck type; remote benzylic; tunable mono ... See more keywords