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   Articles with "hect" as a keyword



A HECT domain ubiquitin ligase CgWWP1 regulates granulocytes proliferation in oyster Crassostrea gigas.

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recommendations! Published in 2021 at "Developmental and comparative immunology"

DOI: 10.1016/j.dci.2021.104148

Abstract: Ubiquitination is involved in the regulation of granulocyte proliferation in vertebrate, and E3 ubiquitin ligase WWP1 has been reported to play an essential role in this process. In the present study, an HECT type E3… read more here.

Keywords: ubiquitin ligase; proliferation; hect; cgwwp1 ... See more keywords
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A Tunable Brake for HECT Ubiquitin Ligases.

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recommendations! Published in 2017 at "Molecular cell"

DOI: 10.1016/j.molcel.2017.03.020

Abstract: The HECT E3 ligases ubiquitinate numerous transcription factors and signaling molecules, and their activity must be tightly controlled to prevent cancer, immune disorders, and other diseases. In this study, we have found unexpectedly that peptide… read more here.

Keywords: hect ubiquitin; tunable brake; ubiquitin ligases; hect ... See more keywords

Structural visualization of HECT-type E3 ligase Ufd4 accepting and transferring ubiquitin to form K29/K48-branched polyubiquitination

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recommendations! Published in 2025 at "Nature Communications"

DOI: 10.1038/s41467-025-59569-6

Abstract: The K29/K48-linked ubiquitination generated by the cooperative catalysis of E3 ligase Ufd4 and Ubr1 is an enhanced protein degradation signal, in which Ufd4 is responsible for introducing K29-linked ubiquitination to K48-linked ubiquitin chains to augment… read more here.

Keywords: hect; ligase ufd4; k48; k29 k48 ... See more keywords

Expanding the inhibitor space of the WWP1 and WWP2 HECT E3 ligases

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recommendations! Published in 2024 at "Journal of Enzyme Inhibition and Medicinal Chemistry"

DOI: 10.1080/14756366.2024.2394895

Abstract: Abstract The HECT E3 ubiquitin ligases 1 (WWP1) and 2 (WWP2) are responsible for the ubiquitin-mediated degradation of key tumour suppressor proteins and are dysregulated in various cancers and diseases. Here we expand their limited… read more here.

Keywords: inhibitor space; hect; wwp2; wwp1 wwp2 ... See more keywords

Genome-Wide Analysis of the HECT-Type E3 Ubiquitin Ligase Gene Family in Nicotiana benthamiana: Evidence Implicating NbHECT6 and NbHECT13 in the Response to Tomato Yellow Leaf Curl Virus Infection

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recommendations! Published in 2025 at "Genes"

DOI: 10.3390/genes16101150

Abstract: Background: The ubiquitin–proteasome system plays a critical role in plant antiviral defense, with HECT-type E3 ubiquitin ligases serving as key regulators of protein turnover. To explore the potential involvement of the HECT gene family in… read more here.

Keywords: hect; nbhect6 nbhect13; virus; gene ... See more keywords