LAUSR

HECT-Type E3 Ubiquitin Ligases in Cancer.

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1 Published in 2019 at "Trends in biochemical sciences"

DOI: 10.1016/j.tibs.2019.08.004

Abstract: Ubiquitination, a post-translational modification that involves a covalent attachment of ubiquitin to a protein substrate, is essential for cellular homeostatic maintenance. At the end of a three-enzyme cascade, E3 ubiquitin ligases (E3s) recruit substrates and… read more here.

Keywords: ligases cancer; type ubiquitin; hect type; ubiquitin ligases ... See more keywords

Involvement of HECT-type E3 ubiquitin ligase genes in salt chemotaxis learning in C. elegans.

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3 Published in 2022 at "Genetics"

DOI: 10.1093/genetics/iyac025

Abstract: The ubiquitin-proteasome system is associated with various phenomena including learning and memory. In this paper, we report that E3 ubiquitin ligase homologs and the proteasome function are involved in taste avoidance learning, a type of… read more here.

Keywords: ligase genes; ubiquitin ligase; avoidance learning; hect type ... See more keywords

Structural mechanisms of HECT-type ubiquitin ligases

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0 Published in 2018 at "Biological Chemistry"

DOI: 10.1515/hsz-2017-0184

Abstract: Abstract Ubiquitin ligases (E3 enzymes) transfer ubiquitin from ubiquitin-conjugating (E2) enzymes to target proteins. By determining the selection of target proteins, modification sites on those target proteins, and the types of ubiquitin modifications that are… read more here.

Keywords: hect enzymes; structural mechanisms; ubiquitin ligases; mechanisms hect ... See more keywords