A Tunable Brake for HECT Ubiquitin Ligases.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular cell"
DOI: 10.1016/j.molcel.2017.03.020
Abstract: The HECT E3 ligases ubiquitinate numerous transcription factors and signaling molecules, and their activity must be tightly controlled to prevent cancer, immune disorders, and other diseases. In this study, we have found unexpectedly that peptide… read more here.
Keywords: hect ubiquitin; tunable brake; ubiquitin ligases; hect ... See more keywords
HECT E3 ubiquitin ligases – emerging insights into their biological roles and disease relevance
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cell Science"
DOI: 10.1242/jcs.228072
Abstract: ABSTRACT Homologous to E6AP C-terminus (HECT) E3 ubiquitin ligases play a critical role in various cellular pathways, including but not limited to protein trafficking, subcellular localization, innate immune response, viral infections, DNA damage responses and… read more here.
Keywords: hect ubiquitin; roles hect; ubiquitin ligases; biological roles ... See more keywords
Exploring the Roles of HERC2 and the NEDD4L HECT E3 Ubiquitin Ligase Subfamily in p53 Signaling and the DNA Damage Response
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2021.659049
Abstract: Cellular homeostasis is governed by the precise expression of genes that control the translation, localization, and termination of proteins. Oftentimes, environmental and biological factors can introduce mutations into the genetic framework of cells during their… read more here.
Keywords: dna damage; hect ubiquitin; damage response; exploring roles ... See more keywords
Emerging roles of the HECT E3 ubiquitin ligases in gastric cancer
Sign Up to like & getrecommendations! Published in 2023 at "Pathology and Oncology Research"
DOI: 10.3389/pore.2023.1610931
Abstract: Gastric cancer (GC) is one of the most pernicious gastrointestinal tumors with extraordinarily high incidence and mortality. Ubiquitination modification of cellular signaling proteins has been shown to play important roles in GC tumorigenesis, progression, and… read more here.
Keywords: ubiquitin ligase; hect ubiquitin; ubiquitin ligases; gastric cancer ... See more keywords
The Roles of NEDD4 Subfamily of HECT E3 Ubiquitin Ligases in Neurodevelopment and Neurodegeneration
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23073882
Abstract: The ubiquitin pathway regulates the function of many proteins and controls cellular protein homeostasis. In recent years, it has attracted great interest in neurodevelopmental and neurodegenerative diseases. Here, we have presented the first review on… read more here.
Keywords: nedd4 subfamily; roles nedd4; ligases neurodevelopment; hect ubiquitin ... See more keywords