The E3 Ubiquitin Ligase HectD1 Suppresses EMT and Metastasis by Targeting the +TIP ACF7 for Degradation.
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2017.12.096
Abstract: Cancer cells exploit the epithelial-to-mesenchymal transition (EMT) program to become metastatic. Cytoskeletal regulators are required in mesenchymal cells where they promote EMT and EMT-induced migration. In a search for regulators of metastasis, we conducted shRNA… read more here.
Keywords: hectd1; degradation; acf7; ligase hectd1 ... See more keywords
Vitamin C Inhibits Ubiquitination of Glutamate Transporter 1 (GLT-1) in Astrocytes by Downregulating HECTD1.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.1c00845
Abstract: Excitatory neurotoxicity caused by the accumulation of glutamate in the synaptic cleft is an important cause of Parkinson's disease (PD). Astrocyte glutamate transporter 1 (GLT-1) is the main transporter responsible for transporting glutamate, and investigations… read more here.
Keywords: glt astrocytes; hectd1; expression; glt expression ... See more keywords
HECTD1 regulates the expression of SNAIL: Implications for epithelial-mesenchymal transition
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Oncology"
DOI: 10.3892/ijo.2020.5002
Abstract: As a transcription factor, SNAIL plays a crucial role in embryonic development and cancer progression by mediating epithelial-mesenchymal transition (EMT); however, post-translational modifications, such as ubiquitination, which control the degradation of SNAIL have been observed… read more here.
Keywords: hectd1; mesenchymal transition; snail; epithelial mesenchymal ... See more keywords