The E3 ligase HECTD3 promotes esophageal squamous cell carcinoma (ESCC) growth and cell survival through targeting and inhibiting caspase-9 activation.
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DOI: 10.1016/j.canlet.2017.07.004
Abstract: Apoptosis resistance is an acquired hallmark of cancer cells and many factors can contribute to the tumor cell apoptosis resistance. In this study, we demonstrated that HECTD3, overexpressed in human esophageal squamous cell carcinoma (ESCC),… read more here.
Keywords: caspase; esophageal squamous; apoptosis; cell survival ... See more keywords
HECTD3 enhances cell radiation resistance and migration by regulating LKB1 mediated ZEB1 in glioma
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DOI: 10.1111/ejn.15748
Abstract: Homologous to the E6‐associated protein carboxyl terminus domain containing 3 (HECTD3) has been reported to play a role in carcinogenesis. Here, we explored the role of HECTD3 in regulating the radiation resistance of glioma, and… read more here.
Keywords: cell; hectd3; radiation resistance; glioma ... See more keywords