Leishmanicidal and cytotoxic activity of hederagenin-bistriazolyl derivatives.
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DOI: 10.1016/j.ejmech.2017.09.045
Abstract: Aiming to obtain new potent leishmanicidal and cytotoxic compounds from natural sources, the triterpene hederagenin was converted into several new 1,2,3-triazolyl derivatives tethered at C-23 and C-28. For this work hederagenin was isolated from fruits… read more here.
Keywords: activity hederagenin; leishmanicidal cytotoxic; hederagenin; activity ... See more keywords
Microbial transformation of hederagenin by Cunninghamella echinulate, Mucor subtilissimus, and Pseudomonas oleovorans
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DOI: 10.1080/10286020.2016.1232252
Abstract: Abstract The pentacyclic triterpenoid hederagenin (1) was subjected to biotransformation by Cunninghamella echinulate CGMCC 3.2000, Mucor subtilissimus CGMCC 3.2454 and Pseudomonas oleovorans CGMCC 1.1641. Three metabolites were obtained. On the basis of nuclear magnetic resonance… read more here.
Keywords: pseudomonas oleovorans; hederagenin; mucor subtilissimus; cunninghamella echinulate ... See more keywords
Hederagenin Exerts Potential Antilipemic Effect via p38MAPK Pathway in Oleic Acid-induced HepG2 cells and in Hyperlipidemic Rats.
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DOI: 10.1590/0001-3765202220201909
Abstract: Hederagenin, a natural compound distributed in many medicinal plants, has a variety of pharmacological properties including anti-bacteria, anti-inflammation, anti-oxidation, and anti- apoptosis.. The aim of this study was to evaluate the effects of hederagenin on… read more here.
Keywords: effect; induced hepg2; acid induced; oleic acid ... See more keywords
Hederagenin Supplementation Alleviates the Pro-Inflammatory and Apoptotic Response to Alcohol in Rats
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DOI: 10.3390/nu9010041
Abstract: In this study, we determined the effects of hederagenin isolated from Akebia quinata fruit on alcohol-induced hepatotoxicity in rats. Specifically, we investigated the hepatoprotective, anti-inflammatory, and anti-apoptotic effects of hederagenin, as well as the role… read more here.
Keywords: group; expression; ethanol induced; hederagenin ... See more keywords