Timing is everything: Transcriptional repression is not the default mode for regulating Hedgehog signaling
Sign Up to like & getrecommendations! Published in 2022 at "BioEssays"
DOI: 10.1002/bies.202200139
Abstract: Hedgehog (HH) signaling is a conserved pathway that drives developmental growth and is essential for the formation of most organs. The expression of HH target genes is regulated by a dual switch mechanism where GLI… read more here.
Keywords: hedgehog signaling; default; hedgehog; gli proteins ... See more keywords
MUC21 controls melanoma progression via regulating SLITRK5 and hedgehog signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11817
Abstract: Mucins are heavily glycosylated proteins secreted by various cell types, to protect the epithelial surface of the gastrointestinal tract from damage. Currently, increasing studies provided evidence to suggest that mucins play an essential role in… read more here.
Keywords: muc21; hedgehog; progression; melanoma progression ... See more keywords
Human osteoprogenitor cells obtained from traumatic heterotopic ossification samples showed enhanced osteogenic differentiation potential and ERK/hedgehog signaling than that from normal bone
Sign Up to like & getrecommendations! Published in 2022 at "IUBMB Life"
DOI: 10.1002/iub.2670
Abstract: Traumatic heterotopic ossification (HO) refers to the abnormal ectopic osteogenesis following trauma, causing limb dysfunction and seriously lowering the life quality of patients. Aberrant osteogenic behavior of progenitor cells that ectopically accumulated within the soft… read more here.
Keywords: hedgehog signaling; heterotopic ossification; osteogenic differentiation; hedgehog ... See more keywords
The Mechanism of Cholesterol Modification of Hedgehog Ligand
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Computational Chemistry"
DOI: 10.1002/jcc.26097
Abstract: Hedgehog (Hh) proteins are important components of signal transduction pathways involved in animal development, and their defects are implicated in carcinogenesis. Their N‐terminal domain (HhN) acts as a signaling ligand, and their C‐terminal domain (HhC)… read more here.
Keywords: mechanism cholesterol; hedgehog; cholesterol; precursor ... See more keywords
Ursolic acid inhibits the activation of smoothened‐independent non‐canonical hedgehog pathway in colorectal cancer by suppressing AKT signaling cascade
Sign Up to like & getrecommendations! Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7523
Abstract: It is being brought to light that smoothened (SMO)‐independent non‐canonical Hedgehog signaling is associated with the pathogenesis of various cancers. Ursolic acid (UA), a pentacyclic triterpenoid present in many medicinal herbs, manifests potent effectiveness against… read more here.
Keywords: signaling cascade; hedgehog; crc; non canonical ... See more keywords
Hedgehog signaling promotes angiogenesis directly and indirectly in pancreatic cancer
Sign Up to like & getrecommendations! Published in 2020 at "Angiogenesis"
DOI: 10.1007/s10456-020-09725-x
Abstract: Introduction The inhibition of Hedgehog (Hh) signaling in pancreatic ductal adenocarcinoma (PDAC) reduces desmoplasia and promotes increased vascularity. In contrast to these findings, the Hh ligand Sonic Hedgehog (SHH) is a potent proangiogenic factor in… read more here.
Keywords: hedgehog signaling; signaling promotes; hedgehog; effect ... See more keywords
Implication de la voie de signalisation Hedgehog dans les mastocytoses
Sign Up to like & getrecommendations! Published in 2020 at "Annales De Dermatologie Et De Venereologie"
DOI: 10.1016/j.annder.2020.09.076
Abstract: Introduction Les mastocytoses sont des neoplasies rares heterogenes liees a l’accumulation clonale de mastocytes dans differents organes. Cette accumulation est a l’origine de manifestations cliniques variees. Des mutations somatiques activatrices dans le gene KIT (comme… read more here.
Keywords: hedgehog; voie; nous avons; dans les ... See more keywords
Concomitant targeting of Hedgehog signaling and MCL-1 synergistically induces cell death in Hedgehog-driven cancer cells.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer letters"
DOI: 10.1016/j.canlet.2019.08.012
Abstract: In the present study, we show that concomitant inhibition of Hedgehog (HH) signaling by the Glioma-Associated Oncogene Homolog1 (GLI1)-targeting agent GANT61 and the antiapoptotic BCL-2 protein family member MCL-1 by A-1210477 synergistically induces cell death… read more here.
Keywords: death; hedgehog; gant61 1210477; cell death ... See more keywords
The interplay of Patched, Smoothened and cholesterol in Hedgehog signaling.
Sign Up to like & getrecommendations! Published in 2019 at "Current opinion in cell biology"
DOI: 10.1016/j.ceb.2019.06.008
Abstract: The Hedgehog (HH) pathway plays a pivotal role in regulating a diverse array of events from embryonic tissue patterning to adult organ self-renewal. Aberrant activation of the pathway is linked to carcinogenesis. Key factors in… read more here.
Keywords: interplay patched; hedgehog; cholesterol; ptch ... See more keywords
CRISPR Screens Uncover Genes that Regulate Target Cell Sensitivity to the Morphogen Sonic Hedgehog
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DOI: 10.1016/j.devcel.2017.12.003
Abstract: Summary To uncover regulatory mechanisms in Hedgehog (Hh) signaling, we conducted genome-wide screens to identify positive and negative pathway components and validated top hits using multiple signaling and differentiation assays in two different cell types.… read more here.
Keywords: cell sensitivity; hedgehog; sonic hedgehog; cell ... See more keywords
CREB Non-autonomously Controls Reproductive Aging through Hedgehog/Patched Signaling.
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DOI: 10.1016/j.devcel.2020.05.023
Abstract: Evolutionarily conserved signaling pathways are crucial for adjusting growth, reproduction, and cell maintenance in response to altered environmental conditions or energy balance. However, we have an incomplete understanding of the signaling networks and mechanistic changes… read more here.
Keywords: reproductive decline; non autonomously; hedgehog; creb ... See more keywords