Structure, mechanism, and inhibition of Hedgehog acyltransferase
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Cell"
DOI: 10.1016/j.molcel.2021.11.018
Abstract: Summary The Sonic Hedgehog (SHH) morphogen pathway is fundamental for embryonic development and stem cell maintenance and is implicated in various cancers. A key step in signaling is transfer of a palmitate group to the… read more here.
Keywords: structure mechanism; hedgehog acyltransferase; structure; mechanism inhibition ... See more keywords
Palmitoylation of Hedgehog proteins by Hedgehog acyltransferase: roles in signalling and disease
Sign Up to like & getrecommendations! Published in 2021 at "Open Biology"
DOI: 10.1098/rsob.200414
Abstract: Hedgehog acyltransferase (Hhat), a member of the membrane-bound O-acyltransferase (MBOAT) family, catalyses the covalent attachment of palmitate to the N-terminus of Hedgehog proteins. Palmitoylation is a post-translational modification essential for Hedgehog signalling. This review explores… read more here.
Keywords: hedgehog acyltransferase; palmitoylation; hedgehog; disease ... See more keywords