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Hedgehog Autoprocessing: From Structural Mechanisms to Drug Discovery

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1 Published in 2022 at "Frontiers in Molecular Biosciences"

DOI: 10.3389/fmolb.2022.900560

Abstract: Hedgehog (Hh) signaling plays pivotal roles in embryonic development. In adults, Hh signaling is mostly turned off but its abnormal activation is involved in many types of cancer. Hh signaling is initiated by the Hh… read more here.

Keywords: structural mechanisms; autoprocessing structural; hedgehog autoprocessing; drug discovery ... See more keywords