Design and Evolution of a Macrocyclic Peptide Inhibitor of the Sonic Hedgehog/Patched Interaction.
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DOI: 10.1021/jacs.7b06087
Abstract: The hedgehog (Hh) signaling pathway plays a central role during embryonic development, and its aberrant activation has been implicated in the development and progression of several human cancers. Major efforts toward the identification of chemical… read more here.
Keywords: peptide; patched interaction; macrocyclic peptide; hedgehog ... See more keywords