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   Articles with "hedgehog pathway" as a keyword



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Design of Hedgehog pathway inhibitors for cancer treatment

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recommendations! Published in 2019 at "Medicinal Research Reviews"

DOI: 10.1002/med.21555

Abstract: Hedgehog (Hh) signaling is involved in the initiation and progression of various cancers and is essential for embryonic and postnatal development. This pathway remains in the quiescent state in adult tissues but gets activated upon… read more here.

Keywords: hedgehog pathway; pathway; pathway inhibitors; cancer ... See more keywords
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Ar-Turmerone Exerts Anti-proliferative and Anti-inflammatory Activities in HaCaT Keratinocytes by Inactivating Hedgehog Pathway

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recommendations! Published in 2019 at "Inflammation"

DOI: 10.1007/s10753-019-01131-w

Abstract: Psoriasis, a common skin inflammatory disorder, is characterized by the aberrant growth and differentiation of keratinocytes. Ar-Turmerone, a main bioactive ingredient of Curcuma longa , has been found to alleviate skin inflammation in psoriasis-like mice.… read more here.

Keywords: turmerone; hedgehog pathway; inflammatory; hacat cells ... See more keywords
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miR-7-5p acts as a tumor suppressor in bladder cancer by regulating the hedgehog pathway factor Gli3.

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recommendations! Published in 2018 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2018.07.166

Abstract: Although important progresses have been made in the diagnosis and treatment of bladder cancer (BCa), the overall survival for patients with advanced BCa remains poor. It is necessary to uncover the molecular mechanism underlying the… read more here.

Keywords: bladder cancer; gli3; bca; hedgehog pathway ... See more keywords
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Hedgehog pathway inhibitors of the acylthiourea and acylguanidine class show antitumor activity on colon cancer in vitro and in vivo.

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recommendations! Published in 2018 at "European journal of medicinal chemistry"

DOI: 10.1016/j.ejmech.2018.07.053

Abstract: Small series of acylguanidine and acylthiourea derivatives were synthesized in gram-scale and assayed for their ability to modulate the Hh signalling pathway. In vitro studies showed a low micromolar inhibitory activity toward tumor cell lines, while… read more here.

Keywords: hedgehog pathway; colon cancer; activity; vivo ... See more keywords
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Practical management of the adverse effects of Hedgehog pathway inhibitor therapy for basal cell carcinoma

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recommendations! Published in 2017 at "Journal of the American Academy of Dermatology"

DOI: 10.1016/j.jaad.2016.04.063

Abstract: REFERENCES 1. Piette EW, Rosenbach M. Granuloma annulare: pathogenesis, disease associations and triggers, and therapeutic options. J Am Acad Dermatol. 2016;75:467-479. 2. Piette EW, Rosenbach M. Granuloma annulare: clinical and histologic variants, epidemiology, and genetics.… read more here.

Keywords: hedgehog pathway; pathway inhibitor; practical management; adverse effects ... See more keywords
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Cilia-Associated Oxysterols Activate Smoothened.

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recommendations! Published in 2018 at "Molecular cell"

DOI: 10.1016/j.molcel.2018.08.034

Abstract: Primary cilia are required for Smoothened to transduce vertebrate Hedgehog signals, but how Smoothened accumulates in cilia and is activated is incompletely understood. Here, we identify cilia-associated oxysterols that promote Smoothened accumulation in cilia and… read more here.

Keywords: cilia associated; oxysterols activate; associated oxysterols; hedgehog pathway ... See more keywords
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Hedgehog pathway mutations are involved in the pathogenesis of plaque-type "trichoblastoma": a report of two cases.

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recommendations! Published in 2023 at "Journal of cutaneous pathology"

DOI: 10.1111/cup.14389

Abstract: We present two cases of plaque-type trichoblastoma with atypical foci. A rare variant of trichoblastoma is the plaque-variant, which is characterized by poor circumscription and locally infiltrative growth pattern. These lesions mostly require multiple stages… read more here.

Keywords: hedgehog pathway; plaque type; type trichoblastoma; trichoblastoma report ... See more keywords
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Hedgehog pathway modulation by glypican 3-conjugated heparan sulfate.

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recommendations! Published in 2022 at "Journal of cell science"

DOI: 10.1242/jcs.259297

Abstract: Glypicans are a family of cell-surface heparan sulfate proteoglycans that play critical roles in multiple cell signaling pathways. Glypicans consist of a globular core, an unstructured stalk modified with sulfated glycosaminoglycan chains, and a glycosylphosphatidylinositol… read more here.

Keywords: hedgehog pathway; pathway modulation; heparan sulfate; sulfate ... See more keywords
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Treatment patterns and outcomes for patients with locally advanced basal cell carcinoma before availability of Hedgehog pathway inhibitors: a retrospective chart review

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recommendations! Published in 2017 at "European Journal of Dermatology"

DOI: 10.1684/ejd.2017.3031

Abstract: BackgroundUnderstanding the molecular basis of basal cell carcinoma (BCC) has led to development of Hedgehog pathway inhibitors (HPIs) for patients with advanced forms of BCC (aBCC). A practical definition of aBCC as a distinct disease… read more here.

Keywords: cell carcinoma; hedgehog pathway; treatment; basal cell ... See more keywords
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Hedgehog Pathway Activation Might Mediate Pemetrexed Resistance in NSCLC Cells

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recommendations! Published in 2020 at "AntiCancer Research"

DOI: 10.21873/anticanres.14087

Abstract: Background/Aim: Resistance to chemotherapeutic agents is the main cause of reduced survival in non-small cell lung cancer (NSCLC) patients. The Hedgehog (HH) pathway has been shown to be crucial in cell development and survival. Activated… read more here.

Keywords: pemetrexed resistance; hedgehog pathway; resistance nsclc; nsclc cells ... See more keywords
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Update on glasdegib in acute myeloid leukemia – broadening horizons of Hedgehog pathway inhibitors

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recommendations! Published in 2021 at "Acta Pharmaceutica"

DOI: 10.2478/acph-2022-0007

Abstract: Abstract Numerous new emerging therapies, including oral targeted chemotherapies, have recently entered the therapeutic arsenal against acute myeloid leukemia (AML). The significant shift toward the use of these novel therapeutics, administered either alone or in… read more here.

Keywords: myeloid leukemia; hedgehog pathway; update glasdegib; acute myeloid ... See more keywords