Palmitoylation of Hedgehog proteins by Hedgehog acyltransferase: roles in signalling and disease
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DOI: 10.1098/rsob.200414
Abstract: Hedgehog acyltransferase (Hhat), a member of the membrane-bound O-acyltransferase (MBOAT) family, catalyses the covalent attachment of palmitate to the N-terminus of Hedgehog proteins. Palmitoylation is a post-translational modification essential for Hedgehog signalling. This review explores… read more here.
Keywords: hedgehog acyltransferase; palmitoylation; hedgehog; disease ... See more keywords
Hedgehog proteins create a dynamic cholesterol interface
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DOI: 10.1371/journal.pone.0246814
Abstract: During formation of the Hedgehog (Hh) signaling proteins, cooperative activities of the Hedgehog INTein (Hint) fold and Sterol Recognition Region (SRR) couple autoproteolysis to cholesterol ligation. The cholesteroylated Hh morphogens play essential roles in embryogenesis,… read more here.
Keywords: proteins create; hedgehog; cholesterol; create dynamic ... See more keywords