Tissue Mechanics and Hedgehog Signaling Crosstalk as a Key Epithelial–Stromal Interplay in Cancer Development (Adv. Sci. 35/2024)
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202470210
Abstract: Cancer Cells' Mastery of Their Environment Cancer cells actively reshape their surroundings. By releasing sonic hedgehog, they stiffen the extracellular matrix, enlisting stromal cells as allies. This increased stiffness heightens actomyosin cytoskeleton tension, activating oncogenic… read more here.
Keywords: cancer; tissue mechanics; hedgehog signaling; mechanics ... See more keywords
The complex web of canonical and non‐canonical Hedgehog signaling
Sign Up to like & getrecommendations! Published in 2022 at "BioEssays"
DOI: 10.1002/bies.202100183
Abstract: Hedgehog (Hh) signaling is a widely studied signaling pathway because of its critical roles during development and in cell homeostasis. Vertebrate canonical and non‐canonical Hh signaling are typically assumed to be distinct and occur in… read more here.
Keywords: hedgehog signaling; canonical non; non canonical; complex web ... See more keywords
Timing is everything: Transcriptional repression is not the default mode for regulating Hedgehog signaling
Sign Up to like & getrecommendations! Published in 2022 at "BioEssays"
DOI: 10.1002/bies.202200139
Abstract: Hedgehog (HH) signaling is a conserved pathway that drives developmental growth and is essential for the formation of most organs. The expression of HH target genes is regulated by a dual switch mechanism where GLI… read more here.
Keywords: hedgehog signaling; default; hedgehog; gli proteins ... See more keywords
Recombinant Ostreolysin Promotes the Browning of Preadipocytes by Inhibiting the Expression of Genes Associated With the Hedgehog Signaling Pathway in db/db Mice
Sign Up to like & getrecommendations! Published in 2025 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.70099
Abstract: Nonalcoholic steatohepatitis (NASH), a highly prevalent metabolic‐related fatty liver disease, has become a major global health issue with limited therapeutic options. Recent studies indicated that ostreolysin (Oly), a protein derived from oyster mushrooms, could be… read more here.
Keywords: recombinant ostreolysin; hedgehog; hedgehog signaling; promotes browning ... See more keywords
Frem1 activity is regulated by Sonic hedgehog signaling in the cranial neural crest mesenchyme during midfacial morphogenesis
Sign Up to like & getrecommendations! Published in 2022 at "Developmental Dynamics"
DOI: 10.1002/dvdy.555
Abstract: Frem1 has been linked to human face shape variation, dysmorphology, and malformation, but little is known about its regulation and biological role in facial development. read more here.
Keywords: hedgehog signaling; activity regulated; sonic hedgehog; frem1 activity ... See more keywords
Human osteoprogenitor cells obtained from traumatic heterotopic ossification samples showed enhanced osteogenic differentiation potential and ERK/hedgehog signaling than that from normal bone
Sign Up to like & getrecommendations! Published in 2022 at "IUBMB Life"
DOI: 10.1002/iub.2670
Abstract: Traumatic heterotopic ossification (HO) refers to the abnormal ectopic osteogenesis following trauma, causing limb dysfunction and seriously lowering the life quality of patients. Aberrant osteogenic behavior of progenitor cells that ectopically accumulated within the soft… read more here.
Keywords: hedgehog signaling; heterotopic ossification; osteogenic differentiation; hedgehog ... See more keywords
Primary Cilia Direct Murine Articular Cartilage Tidemark Patterning Through Hedgehog Signaling and Ambulatory Load
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.4506
Abstract: Articular cartilage (AC) is essential for body movement but is highly susceptible to degenerative diseases and has poor self‐repair capacity. To improve current subpar regenerative treatments, developmental mechanisms of AC should be clarified and, specifically,… read more here.
Keywords: hedgehog signaling; tidemark; tidemark patterning; load ... See more keywords
Overexpression of microRNA‐186 inhibits angiogenesis in retinoblastoma via the Hedgehog signaling pathway by targeting ATAD2
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28545
Abstract: Retinoblastoma (RB) represents an aggressive malignancy in the eye during the period of infancy and childhood. We delineated the ability of microRNA‐186 (miR‐186) to influence viability, invasion, migration, angiogenesis, and apoptosis of RB via the… read more here.
Keywords: microrna 186; hedgehog signaling; angiogenesis; signaling pathway ... See more keywords
Strategies to target the Hedgehog signaling pathway for cancer therapy
Sign Up to like & getrecommendations! Published in 2018 at "Medicinal Research Reviews"
DOI: 10.1002/med.21482
Abstract: Hedgehog (Hh) signaling is an essential pathway in the human body, and plays a major role in embryo development and tissue patterning. Constitutive activation of the Hh signaling pathway through sporadic mutations or other mechanisms… read more here.
Keywords: hedgehog signaling; target hedgehog; signaling pathway; pathway ... See more keywords
Hedgehog signaling promotes angiogenesis directly and indirectly in pancreatic cancer
Sign Up to like & getrecommendations! Published in 2020 at "Angiogenesis"
DOI: 10.1007/s10456-020-09725-x
Abstract: Introduction The inhibition of Hedgehog (Hh) signaling in pancreatic ductal adenocarcinoma (PDAC) reduces desmoplasia and promotes increased vascularity. In contrast to these findings, the Hh ligand Sonic Hedgehog (SHH) is a potent proangiogenic factor in… read more here.
Keywords: hedgehog signaling; signaling promotes; hedgehog; effect ... See more keywords
Saikosaponin B1 and Saikosaponin D inhibit tumor growth in medulloblastoma allograft mice via inhibiting the Hedgehog signaling pathway.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of natural medicines"
DOI: 10.1007/s11418-022-01603-8
Abstract: Medulloblastoma (MB), accounting for nearly 10% of all childhood brain tumors, are implicated with aberrant activation of the Hedgehog (Hh) signaling pathway. Saikosaponin B1 (SSB1) and Saikosaponin D (SSD), two bioactive constituents of Radix Bupleuri,… read more here.
Keywords: tumor; hedgehog signaling; tumor growth; signaling pathway ... See more keywords