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Published in 2022 at "BioEssays"
DOI: 10.1002/bies.202100183
Abstract: Hedgehog (Hh) signaling is a widely studied signaling pathway because of its critical roles during development and in cell homeostasis. Vertebrate canonical and non‐canonical Hh signaling are typically assumed to be distinct and occur in…
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Keywords:
hedgehog signaling;
canonical non;
non canonical;
complex web ... See more keywords
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Published in 2022 at "BioEssays"
DOI: 10.1002/bies.202200139
Abstract: Hedgehog (HH) signaling is a conserved pathway that drives developmental growth and is essential for the formation of most organs. The expression of HH target genes is regulated by a dual switch mechanism where GLI…
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Keywords:
hedgehog signaling;
default;
hedgehog;
gli proteins ... See more keywords
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Published in 2022 at "Developmental Dynamics"
DOI: 10.1002/dvdy.555
Abstract: Frem1 has been linked to human face shape variation, dysmorphology, and malformation, but little is known about its regulation and biological role in facial development.
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Keywords:
hedgehog signaling;
activity regulated;
sonic hedgehog;
frem1 activity ... See more keywords
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Published in 2022 at "IUBMB Life"
DOI: 10.1002/iub.2670
Abstract: Traumatic heterotopic ossification (HO) refers to the abnormal ectopic osteogenesis following trauma, causing limb dysfunction and seriously lowering the life quality of patients. Aberrant osteogenic behavior of progenitor cells that ectopically accumulated within the soft…
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Keywords:
hedgehog signaling;
heterotopic ossification;
osteogenic differentiation;
hedgehog ... See more keywords
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Published in 2022 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.4506
Abstract: Articular cartilage (AC) is essential for body movement but is highly susceptible to degenerative diseases and has poor self‐repair capacity. To improve current subpar regenerative treatments, developmental mechanisms of AC should be clarified and, specifically,…
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Keywords:
hedgehog signaling;
tidemark;
tidemark patterning;
load ... See more keywords
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Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28545
Abstract: Retinoblastoma (RB) represents an aggressive malignancy in the eye during the period of infancy and childhood. We delineated the ability of microRNA‐186 (miR‐186) to influence viability, invasion, migration, angiogenesis, and apoptosis of RB via the…
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Keywords:
microrna 186;
hedgehog signaling;
angiogenesis;
signaling pathway ... See more keywords
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Published in 2018 at "Medicinal Research Reviews"
DOI: 10.1002/med.21482
Abstract: Hedgehog (Hh) signaling is an essential pathway in the human body, and plays a major role in embryo development and tissue patterning. Constitutive activation of the Hh signaling pathway through sporadic mutations or other mechanisms…
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Keywords:
hedgehog signaling;
target hedgehog;
signaling pathway;
pathway ... See more keywords
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Published in 2020 at "Angiogenesis"
DOI: 10.1007/s10456-020-09725-x
Abstract: Introduction The inhibition of Hedgehog (Hh) signaling in pancreatic ductal adenocarcinoma (PDAC) reduces desmoplasia and promotes increased vascularity. In contrast to these findings, the Hh ligand Sonic Hedgehog (SHH) is a potent proangiogenic factor in…
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Keywords:
hedgehog signaling;
signaling promotes;
hedgehog;
effect ... See more keywords
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Published in 2022 at "Journal of natural medicines"
DOI: 10.1007/s11418-022-01603-8
Abstract: Medulloblastoma (MB), accounting for nearly 10% of all childhood brain tumors, are implicated with aberrant activation of the Hedgehog (Hh) signaling pathway. Saikosaponin B1 (SSB1) and Saikosaponin D (SSD), two bioactive constituents of Radix Bupleuri,…
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Keywords:
tumor;
hedgehog signaling;
tumor growth;
signaling pathway ... See more keywords
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Published in 2020 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2020.109189
Abstract: Di-n-butyl phthalate (DBP) is a pollutant that is widely present in the environment. We have previously demonstrated that maternal exposure to DBP resulted in renal fibrosis in offspring, but the underlying mechanism was not well…
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Keywords:
hedgehog signaling;
exposure;
tubular cells;
renal tubular ... See more keywords
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Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.11.025
Abstract: Colon cancer is a heterogeneous tumor driven by a subpopulation of cancer stem cells (CSCs). To study CSCs in colon cancer, we used limiting dilution spheroid and serial xenotransplantation assays to functionally define the frequency of…
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Keywords:
cancer;
regulator wnt;
hedgehog signaling;
colon cancer ... See more keywords