Emerging roles of the Hedgehog signalling pathway in inflammatory bowel disease
Sign Up to like & getrecommendations! Published in 2021 at "Cell Death Discovery"
DOI: 10.1038/s41420-021-00679-7
Abstract: The Hedgehog (Hh) signalling pathway plays a critical role in the growth and patterning during embryonic development and maintenance of adult tissue homeostasis. Emerging data indicate that Hh signalling is implicated in the pathogenesis of… read more here.
Keywords: bowel disease; inflammatory bowel; signalling pathway; role ... See more keywords
Canonical hedgehog signalling regulates hepatic stellate cell‐mediated angiogenesis in liver fibrosis
Sign Up to like & getrecommendations! Published in 2017 at "British Journal of Pharmacology"
DOI: 10.1111/bph.13701
Abstract: Hepatic stellate cells (HSCs) are liver‐specific pericytes regulating angiogenesis during liver fibrosis. We aimed to elucidate the mechanisms by which hedgehog signalling regulated HSC angiogenic properties and to validate the therapeutic implications. read more here.
Keywords: hedgehog signalling; angiogenesis liver; hepatic stellate; liver fibrosis ... See more keywords
Acyltransferase skinny hedgehog regulates TGFβ-dependent fibroblast activation in SSc
Sign Up to like & getrecommendations! Published in 2019 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2019-215066
Abstract: Objectives Systemic sclerosis (SSc) is characterised by aberrant hedgehog signalling in fibrotic tissues. The hedgehog acyltransferase (HHAT) skinny hedgehog catalyses the attachment of palmitate onto sonic hedgehog (SHH). Palmitoylation of SHH is required for multimerisation… read more here.
Keywords: ssc; tgf dependent; hedgehog; hedgehog signalling ... See more keywords
Targeting the Hedgehog signalling pathway in triple negative breast cancer.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.15_suppl.e24216
Abstract: e24216Background: Paracrine Hedgehog (Hh) signalling occurs in ~30% of all triple negative breast cancers (TNBCs) and confers worse overall survival. The tumour stroma has been shown to facilitate ... read more here.
Keywords: hedgehog signalling; negative breast; targeting hedgehog; triple negative ... See more keywords
WDR11‐mediated Hedgehog signalling defects underlie a new ciliopathy related to Kallmann syndrome
Sign Up to like & getrecommendations! Published in 2018 at "EMBO Reports"
DOI: 10.15252/embr.201744632
Abstract: WDR11 has been implicated in congenital hypogonadotropic hypogonadism (CHH) and Kallmann syndrome (KS), human developmental genetic disorders defined by delayed puberty and infertility. However, WDR11's role in development is poorly understood. Here, we report that… read more here.
Keywords: hedgehog signalling; kallmann syndrome; ciliopathy; wdr11 ... See more keywords