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   Articles with "hei oc1" as a keyword



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Differentiation of embryonic stem cells into a putative hair cell-progenitor cells via co-culture with HEI-OC1 cells

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recommendations! Published in 2021 at "Scientific Reports"

DOI: 10.1038/s41598-021-93049-3

Abstract: Several studies have shown how different cell lines can influence the differentiation of stem cells through co-culture systems. The House Ear Institute-Organ of Corti 1 (HEI-OC1) is considered an important cell line for in vitro… read more here.

Keywords: culture; oc1 cells; differentiation; hei oc1 ... See more keywords
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PIN1 Protects Hair Cells and Auditory HEI-OC1 Cells against Senescence by Inhibiting the PI3K/Akt/mTOR Pathway

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recommendations! Published in 2021 at "Oxidative Medicine and Cellular Longevity"

DOI: 10.1155/2021/9980444

Abstract: A growing amount of evidence has confirmed the crucial role of the prolyl isomerase PIN1 in aging and age-related diseases. However, the mechanism of PIN1 in age-related hearing loss (ARHL) remains unclear. Pathologically, ARHL is… read more here.

Keywords: oc1 cells; hei oc1; hair cells; senescence ... See more keywords
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Nrf2 Knockout Affected the Ferroptosis Signaling Pathway against Cisplatin-Induced Hair Cell-Like HEI-OC1 Cell Death

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recommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"

DOI: 10.1155/2022/2210733

Abstract: Cisplatin is a well-known and widely used anticancer drug with high therapeutic efficacy in solid tumors; however, side effects are common with its use. Because cisplatin can be retained in the cochlea, ototoxicity leading to… read more here.

Keywords: nrf2 knockout; cell; hei oc1; cisplatin induced ... See more keywords

Melatonin Attenuates Cisplatin-Induced Ototoxicity via Regulating the Cell Apoptosis of the Inner Ear

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recommendations! Published in 2022 at "Computational and Mathematical Methods in Medicine"

DOI: 10.1155/2022/7160816

Abstract: Objective The mechanism of ototoxicity caused by cisplatin is currently unclear, and the induced apoptosis may play an important role in inner ear injury. Melatonin has high antioxidant and antiapoptotic effects. This study is aimed… read more here.

Keywords: oc1 cells; apoptosis; inner ear; ototoxicity ... See more keywords
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Glucocorticoids protect HEI-OC1 cells from tunicamycin-induced cell damage via inhibiting endoplasmic reticulum stress

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recommendations! Published in 2021 at "Open Life Sciences"

DOI: 10.1515/biol-2021-0057

Abstract: Abstract Background To analyze mechanisms of action of glucocorticoid treatment for endoplasmic reticulum stress (ERS) in sensorineural hearing loss (SNHL), we aimed to evaluate the expression and activation status of the protein kinase RNA-like ER… read more here.

Keywords: oc1 cells; endoplasmic reticulum; hei oc1; reticulum stress ... See more keywords
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NPC1 Deficiency Contributes to Autophagy-Dependent Ferritinophagy in HEI-OC1 Auditory Cells

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recommendations! Published in 2022 at "Frontiers in Molecular Biosciences"

DOI: 10.3389/fmolb.2022.952608

Abstract: Niemann–Pick type C disease (NPCD) is a rare genetic syndrome characterized by cholesterol accumulation in multiple organelles. NPCD is mainly caused by gene deficiency of NPC intracellular cholesterol transporter 1 (NPC1). It has been reported… read more here.

Keywords: autophagy dependent; dependent ferritinophagy; deficiency; auditory cells ... See more keywords
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The Ameliorative Effect of JNK Inhibitor D-JNKI-1 on Neomycin-Induced Apoptosis in HEI-OC1 Cells

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recommendations! Published in 2022 at "Frontiers in Molecular Neuroscience"

DOI: 10.3389/fnmol.2022.824762

Abstract: Aminoglycosides can cause ototoxicity and lead to hair cell damage. Neomycin-induced ototoxicity is related to increased production of reactive oxygen species (ROS) and triggering hair cell apoptosis. The c-Jun-N-terminal kinase (JNK) pathway plays an essential… read more here.

Keywords: cell; apoptosis; jnk; hei oc1 ... See more keywords

IGF-1 Controls Metabolic Homeostasis and Survival in HEI-OC1 Auditory Cells through AKT and mTOR Signaling

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recommendations! Published in 2023 at "Antioxidants"

DOI: 10.3390/antiox12020233

Abstract: Insulin-like growth factor 1 (IGF-1) is a trophic factor for the nervous system where it exerts pleiotropic effects, including the regulation of metabolic homeostasis. IGF-1 deficiency induces morphological alterations in the cochlea, apoptosis and hearing… read more here.

Keywords: hei oc1; oc1 auditory; igf; metabolic homeostasis ... See more keywords

Increased mitochondrial DNA copy number protects hair cells and HEI-OC1 cells against drug-induced apoptosis

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recommendations! Published in 2019 at "Molecular Medicine Reports"

DOI: 10.3892/mmr.2019.10838

Abstract: Several factors trigger apoptosis in cochlear hair cells. Previous studies have shown that mitochondria play key roles in apoptosis, but the role of mitochondrial deoxyribonucleic acid (mtDNA) copy number in the pathogenesis of hair cell… read more here.

Keywords: copy number; oc1 cells; hei oc1; apoptosis ... See more keywords