Harnessing secretory pathway differences between HEK293 and CHO to rescue production of difficult to express proteins.
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DOI: 10.1016/j.ymben.2022.03.009
Abstract: Biologics represent the fastest growing group of therapeutics, but many advanced recombinant protein moieties remain difficult to produce. Here, we identify metabolic engineering targets limiting expression of recombinant human proteins through a systems biology analysis… read more here.
Keywords: expression; difficult express; secretory pathway; express proteins ... See more keywords