Design and Synthesis of Cytotoxic Water-Soluble Rocaglaol Derivatives against HEL Cells by Inhibiting Fli-1.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.3c00948
Abstract: Rocaglaol, embedding a cyclopenta[b]benzofuran scaffold, was isolated mainly from the plants of Aglaia and exhibited nanomolar level antitumor activity. However, the drug-like properties of these compounds are poor. To improve the physicochemical properties of rocaglaol,… read more here.
Keywords: water; rocaglaol derivatives; hel cells; soluble derivative ... See more keywords
L1, a 3,3′-diindolylmethane-derivative, induced ER stress-mediated apoptosis and suppressed growth through the FLI1/AKT pathway in erythroleukemia HEL cells
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2025.1564199
Abstract: Introduction 3,3′-Diindolylmethane (DIM) is a major phytochemical product derived from ingestion of cruciferous vegetables. As an effective cancer chemopreventive agent, DIM has been used in preclinical and clinical trials. Recently, our group synthesized and modified… read more here.
Keywords: analysis; stress; hel cells; fli1 akt ... See more keywords