Exploring the Gallic and Cinnamic Acids Chimeric Derivatives as Anticancer Agents over HeLa Cell Line: An in silico and in vitro Study
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Informatics"
DOI: 10.1002/minf.202200016
Abstract: Cervical cancer is one of the most aggressive and important cancer types in the female population, due to its low survival rate. Actually, the search for new bioactive compounds, like gallic and cinnamic acid, is… read more here.
Keywords: cell line; gallic cinnamic; hela cell; study ... See more keywords
Functional analysis of down-regulated miRNA-221-5p in HeLa cell treated with polyphenol-rich Polyalthia longifolia as regulators of apoptotic HeLa cell death
Sign Up to like & getrecommendations! Published in 2020 at "3 Biotech"
DOI: 10.1007/s13205-020-02193-6
Abstract: MicroRNAs are endogenous small non-coding-RNAs that control gene expression and cancer development. Previous studies reported that Polyalthia longifolia treatment induced apoptotic cell death in HeLa cells by down-regulation of miR-221-5p. Hence, the current study was… read more here.
Keywords: hela cell; mir 221; expression; hela ... See more keywords
Biological evaluation of a halogenated triterpenoid, 2α-bromo-dihydrobelulonic acid as inhibitor of human topoisomerase IIα and HeLa cell proliferation.
Sign Up to like & getrecommendations! Published in 2017 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2017.02.015
Abstract: BACKGROUND The pentacyclic lupane-type (6-6-6-6-5 type) triterpenoid, Betulinic acid (BA) is a potent inhibitor of topoisomerases and is of immense interest as anticancer drugs. However, the compound being highly lipophilic, has limited in vivo uptake capacity.… read more here.
Keywords: hela cell; inhibitor; cell proliferation; topoisomerase ... See more keywords
Chitosan microparticles as entrapment system for trans-cinnamaldehyde: Synthesis, drug loading, and in vitro cytotoxicity evaluation.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2020.10.188
Abstract: The ionic gelation method was used to study the effect of the crosslinking agent, sodium tripolyphosphate on average particle size (Dp) and zeta potential (ζp) of chitosan microparticles (CSMP) unloaded and loaded with trans-cinnamaldehyde (TCIN).… read more here.
Keywords: chitosan microparticles; hela cell; trans cinnamaldehyde; mdck hela ... See more keywords
Synthesis and characterization of a spiroindolone pyrothiazole analog via X-ray, biological, and computational studies
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2019.03.032
Abstract: Abstract Synthetic and natural spiroxindoles are important anti-inflammatory, antibacterial, antileishmanial, and anticancer agents. In this study, we prepared a spiroxindole derivative and evaluated the preliminary results of its biological activity including anti-inflammatory, antileishmanial, and cytotoxic… read more here.
Keywords: ic50; analog; activity; anti inflammatory ... See more keywords
Effect of secondary metabolites of Berberis vulgaris and Petasites hybridus on apoptosis and cell cycle of HeLa cell line.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2021.39.15_suppl.e15063
Abstract: e15063 Background: The study of the possible antitumor activity of secondary plant metabolites either in the form of individual agents or in combination with clinically used drugs is considered as a promising direction in the… read more here.
Keywords: cell line; hela cell; apoptosis; hela ... See more keywords
Calcitriol potentially alters HeLa cell viability via inhibition of autophagy
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cancer Research and Therapeutics"
DOI: 10.4103/jcrt.jcrt_82_20
Abstract: Objective: This study was conducted to evaluate the effect of Calcitriol on cellular death in HeLa cells via autophagy and turn over due to mitochondria homeostasis. Methods: HeLa cell lines were grown in 24-well plates… read more here.
Keywords: hela cell; inhibition; calcitriol; hela cells ... See more keywords
Real-Time Cell Analysis of the Cytotoxicity of Origanum acutidens Essential Oil on HT-29 and HeLa Cell Lines
Sign Up to like & getrecommendations! Published in 2017 at "Turkish Journal of Pharmaceutical Sciences"
DOI: 10.4274/tjps.40427
Abstract: Objectives: The aim of this study was to investigate the cytotoxic and radical scavenging effects of the essential oil from Origanum acutidens (Hand-Mazz.) Ietswaart and to determine its chemical composition. Materials and Methods: The essential… read more here.
Keywords: essential oil; hela cell; cell lines; effect ... See more keywords
Rational Design, Synthesis and Cytotoxic Activity of N-(Phenylcarbamoyl)Benzamide on HeLa Cell Lines
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Mathematical and Fundamental Sciences"
DOI: 10.5614/j.math.fund.sci.2020.52.2.3
Abstract: Urea derivatives are extensively used in the pharmaceutical industry. However, the unsatisfactory level of their membrane penetration requires further modification of the structures with stronger lipophillic properties. Phenylurea has a phenyl group that enables easier… read more here.
Keywords: hela cell; activity; cell lines; phenylcarbamoyl benzamide ... See more keywords