The amphipathic design in helical antimicrobial peptides
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DOI: 10.1002/cmdc.202300480
Abstract: Amphipathicity is a critical characteristic of helical antimicrobial peptides (AMPs). The hydrophilic region, primarily composed of cationic residues, plays a pivotal role in the initial binding to negatively charged components on bacterial membranes through electrostatic… read more here.
Keywords: helical antimicrobial; amphipathic design; design helical; design ... See more keywords
To Fold or Not to Fold: Diastereomeric Optimization of an α-Helical Antimicrobial Peptide.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.3c00460
Abstract: Membrane disruptive α-helical antimicrobial peptides (AMPs) offer an opportunity to address multidrug resistance; however, most AMPs are toxic and unstable in serum. These limitations can be partly overcome by introducing D-residues, which often confers protease… read more here.
Keywords: diastereomeric optimization; fold diastereomeric; optimization helical; fold fold ... See more keywords