Design and Optimization of an α-Helical Bundle Dimer Cell-Penetrating Peptide for In Vivo Drug Delivery.
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DOI: 10.1021/acs.bioconjchem.2c00518
Abstract: To deliver membrane-impermeable drugs into eukaryotic cells, a lot of cell-penetrating peptides (CPPs) were discovered. Previously we designed an amphipathic α-helical peptide which dimerizes itself via its two C-residues. This bis-disulfide-linked dimeric bundle, LK-3, has… read more here.
Keywords: cell; helical bundle; optimization helical; cell penetrating ... See more keywords
Serine 408 phosphorylation is a molecular switch that regulates structure and function of the occludin α-helical bundle
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2204618119
Abstract: Significance Tight junctions form selectively permeable seals that limit paracellular flux. Increased tight junction permeability has been associated with intestinal disease. Previous studies indicate that casein kinase 2 (CK2) phosphorylates S408 within an unstructured region… read more here.
Keywords: tight junction; phosphorylation; helical bundle; serine 408 ... See more keywords