Exploring Helical Folding in Oligomers of Cyclopentane‐Based ϵ‐Amino Acids: A Computational Study
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DOI: 10.1002/open.202100253
Abstract: Abstract The conformational preferences of oligopeptides of an ϵ‐amino acid (2‐((1R,3S)‐3‐(aminomethyl)cyclopentyl)acetic acid, Amc5a) with a cyclopentane substituent in the Cβ−Cγ−Cδ sequence of the backbone were investigated using DFT methods in chloroform and water. The most… read more here.
Keywords: helical folding; conformation; exploring helical; helical conformation ... See more keywords
Enzyme-assisted peptide folding, assembly and anti-cancer properties.
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DOI: 10.1039/c7nr04370h
Abstract: The α-helix is the most prevalent conformation in proteins. However, formation of the α-helical conformation remains a challenge for short peptides with less than 5 amino acids. We demonstrated in this study that enzyme-instructed self-assembly… read more here.
Keywords: self assembly; conformation; peptide folding; helical conformation ... See more keywords