Computational design of the helical hairpin structure of membrane-active antibacterial peptides based on RSV glycoprotein epitope scaffold
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DOI: 10.1016/j.compbiolchem.2018.02.013
Abstract: Peptides with helical hairpin conformation have been found to possess potent membrane activity and can be exploited as the structural scaffold of antibacterial peptides (ABPs). Here, we attempted to computationally design membrane-active ABPs based on… read more here.
Keywords: membrane active; hairpin; rsv glycoprotein; antibacterial peptides ... See more keywords
A minimal helical-hairpin motif provides molecular-level insights into misfolding and pharmacological rescue of CFTR
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DOI: 10.1038/s42003-018-0153-0
Abstract: Our meagre understanding of CFTR misfolding and its reversal by small-molecule correctors hampers the development of mechanism-based therapies of cystic fibrosis. Here we exploit a helical-hairpin construct—the simplest proxy of membrane-protein tertiary contacts—containing CFTR’s transmembrane… read more here.
Keywords: molecular level; cftr; level insights; hairpin ... See more keywords