Anisotropic ESCRT-III architecture governs helical membrane tube formation
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DOI: 10.1038/s41467-020-15327-4
Abstract: ESCRT-III proteins assemble into ubiquitous membrane-remodeling polymers during many cellular processes. Here we describe the structure of helical membrane tubes that are scaffolded by bundled ESCRT-III filaments. Cryo-ET reveals how the shape of the helical… read more here.
Keywords: escrt iii; helical membrane; membrane tube; membrane remodeling ... See more keywords
Methods to study folding of alpha-helical membrane proteins in lipids
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DOI: 10.1098/rsob.220054
Abstract: How alpha-helical membrane proteins fold correctly in the highly hydrophobic membrane interior is not well understood. Their folding is known to be highly influenced by the lipids within the surrounding bilayer, but the majority of… read more here.
Keywords: membrane proteins; helical membrane; folding methods; study folding ... See more keywords
Cell-Free Expression to Probe Co-Translational Insertion of an Alpha Helical Membrane Protein
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DOI: 10.3389/fmolb.2022.795212
Abstract: The majority of alpha helical membrane proteins fold co-translationally during their synthesis on the ribosome. In contrast, most mechanistic folding studies address refolding of full-length proteins from artificially induced denatured states that are far removed… read more here.
Keywords: topology; cell free; helical membrane; alpha helical ... See more keywords