Stabilization of elongated polyglutamine tracts by a helical peptide derived from N‐terminal huntingtin
Sign Up to like & getrecommendations! Published in 2020 at "IUBMB Life"
DOI: 10.1002/iub.2288
Abstract: In Huntington's disease, the length of the polyglutamine tract in the mutant protein correlates positively with the formation of aggregates and disease symptoms and severity of the disease. Some disease‐modifying factors exist. However, no organized… read more here.
Keywords: huntingtin; length; aggregation; peptide ... See more keywords
Targeting the amyloid-β fibril surface by constrained helical peptide inhibitor.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemistry"
DOI: 10.1021/acs.biochem.9b00800
Abstract: Amyloid-β (Aβ) oligomers are well-known toxic molecular species associated with Alzheimer's disease. Recent discoveries of the ability of amyloid fibril surfaces to convert soluble proteins into toxic oligomers suggested that these surfaces could serve as… read more here.
Keywords: helical peptide; surface; fibril surface; amyloid fibril ... See more keywords
A minimal length rigid helical peptide motif allows rational design of modular surfactants
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DOI: 10.1038/ncomms14018
Abstract: Extensive work has been invested in the design of bio-inspired peptide emulsifiers. Yet, none of the formulated surfactants were based on the utilization of the robust conformation and self-assembly tendencies presented by the hydrophobins, which… read more here.
Keywords: helical peptide; minimal length; length rigid; rigid helical ... See more keywords
Directional assembly of a stapled α-helical peptide.
Sign Up to like & getrecommendations! Published in 2019 at "Chemical communications"
DOI: 10.1039/c9cc04591k
Abstract: The de novo design of stapled peptide-based self-assemblies attracts vast interest, yet still remains challenging. The development of an oxidation trigger for peptide stapling and subsequent self-assembly is described here. A self-assembling sequence, Fmoc-R(RCEX)2-NH2, transformed… read more here.
Keywords: directional assembly; helical peptide; assembly stapled; self ... See more keywords
Synthetic helical peptide capping strategies.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Society reviews"
DOI: 10.1039/d1cs01175h
Abstract: Relatively small mimics of interface secondary structures can be used to disrupt protein-protein interactions (PPIs). This strategy is valuable because many PPIs are pivotal in cell biology and contemporary medicinal chemistry. Small peptides tend to… read more here.
Keywords: capping strategies; peptide; peptide capping; synthetic helical ... See more keywords
Atomic insight into short helical peptide comprised of consecutive multiple aromatic residues.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc01038k
Abstract: The occurrence of sequential multiple aromatic residues in a helical sequence is rare compared to the β-sheet rich structure. Here, using helix promoting α-aminoisobutyric acid (Aib) residues, we unravel atomistic details of the helical secondary… read more here.
Keywords: aromatic residues; insight short; multiple aromatic; atomic insight ... See more keywords
A guided tour through α-helical peptide antibiotics and their targets.
Sign Up to like & getrecommendations! Published in 2023 at "Bioscience reports"
DOI: 10.1042/bsr20230474
Abstract: Nowadays, not only biologists, but also researchers from other disciplines such as chemistry, pharmacy, material sciences, or physics are working with antimicrobial peptides. This review is written for researchers and students working in or interested… read more here.
Keywords: guided tour; antibiotics targets; tour helical; design ... See more keywords
In-Tether Chiral Center Induced Helical Peptide Modulators Target p53-MDM2/MDMX and Inhibit Tumor Growth in Stem-Like Cancer Cell: Erratum
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DOI: 10.7150/thno.31152
Abstract: [This corrects the article DOI: 10.7150/thno.19840.]. read more here.
Keywords: center induced; tether chiral; helical peptide; peptide modulators ... See more keywords