Synthetic α‐Helical Peptides as Potential Inhibitors of the ACE2 SARS‐CoV‐2 Interaction
Sign Up to like & getrecommendations! Published in 2022 at "Chembiochem"
DOI: 10.1002/cbic.202200372
Abstract: During viral cell entry, the spike protein of SARS‐CoV‐2 binds to the α1‐helix motif of human angiotensin‐converting enzyme 2 (ACE2). Thus, alpha‐helical peptides mimicking this motif may serve as inhibitors of viral cell entry. For this… read more here.
Keywords: peptides potential; potential inhibitors; helical peptides; synthetic helical ... See more keywords
Ordered Nanofibers Fabricated from Hierarchical Self-Assembling Processes of Designed α-Helical Peptides.
Sign Up to like & getrecommendations! Published in 2020 at "Small"
DOI: 10.1002/smll.202003945
Abstract: Peptide self-assembly is fast evolving into a powerful method for the development of bio-inspired nanomaterials with great potential for many applications, but it remains challenging to control the self-assembling processes and nanostrucutres because of the… read more here.
Keywords: self assembling; helical peptides; assembling processes; self ... See more keywords
Interchain doubly-bridged α-helical peptides for the development of protein binders
Sign Up to like & getrecommendations! Published in 2019 at "Chinese Chemical Letters"
DOI: 10.1016/j.cclet.2019.02.013
Abstract: Abstract Constrained peptide scaffolds that are tolerant to extensive sequence manipulation and amenable to bioactive peptide design are of great value to the development of novel protein binders and peptide therapeutics. In this work, we… read more here.
Keywords: protein binders; doubly bridged; helical peptides; bridged helical ... See more keywords
Designed helical peptides as functional probes for γ-secretase.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemistry"
DOI: 10.1021/acs.biochem.9b00639
Abstract: γ-Secretase is a membrane-embedded aspartyl protease complex with presenilin as the catalytic component that cleaves within the transmembrane domain (TMD) of >90 known substrates, including the amyloid precursor protein (APP) of Alzheimer's disease. Processing by… read more here.
Keywords: helical peptides; functional probes; app; probes secretase ... See more keywords
Stapled Helical Peptides Bearing Different Anchoring Residues.
Sign Up to like & getrecommendations! Published in 2020 at "Chemical reviews"
DOI: 10.1021/acs.chemrev.0c00532
Abstract: A large proportion of protein-protein interactions (PPIs) occur between a short peptide and a globular protein domain; the peptides involved in surface interactions play important roles, and there is great promise for using peptide motifs… read more here.
Keywords: helical peptides; protein interactions; different anchoring; anchoring residues ... See more keywords
High-Throughput Screening of Stapled Helical Peptides in Drug Discovery.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01541
Abstract: Therapeutic peptides have revolutionized treatment for a number of human diseases. In particular, the past two decades have witnessed rapid progress of stapled helical peptides in drug discovery. Stapled helical peptides are chemically modified and… read more here.
Keywords: drug discovery; stapled helical; helical peptides; throughput screening ... See more keywords
Structure-Based Rational Design of Small α-Helical Peptides with Broad-Spectrum Activity against Multidrug-Resistant Pathogens
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.2c01708
Abstract: A series of small (7–12 mer) amphipathic cationic peptides were designed and synthesized to create short helical peptides with broad-range bactericidal activity and selectivity toward the bacterial cells. The analysis identified a lead 12-mer peptide… read more here.
Keywords: helical peptides; spectrum activity; peptides broad; activity ... See more keywords
Co-assembly of helical β3-peptides: a self-assembled analogue of a statistical copolymer
Sign Up to like & getrecommendations! Published in 2017 at "Pure and Applied Chemistry"
DOI: 10.1515/pac-2017-0709
Abstract: Abstract Unnatural peptide self-assembly offers the means to design hierarchical nanostructures of controlled geometries, chemical function and physical properties. N-acyl β3 peptides, where all residues are unnatural amino acids, are able to form helical fibrous… read more here.
Keywords: self assembly; helical peptides; assembled analogue; self assembled ... See more keywords
Understanding Proton Transfer in Non-aqueous Biopolymers based on Helical Peptides: A Quantum Mechanical Study.
Sign Up to like & getrecommendations! Published in 2022 at "International journal of quantum chemistry"
DOI: 10.22541/au.164138957.75951624/v1
Abstract: Histidine (an imidazole-based amino acid) is a promising building block for short aromatic peptides containing a proton donor/acceptor moiety. Previous studies have shown that polyalanine helical peptides substituted at regular intervals with histidine residues exhibit… read more here.
Keywords: helical peptides; proton transfer; non aqueous; energy ... See more keywords