A positively charged surface patch on the pestivirus NS3 protease module plays an important role in modulating NS3 helicase activity and virus production.
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DOI: 10.1007/s00705-021-05055-5
Abstract: Pestivirus nonstructural protein 3 (NS3) is a multifunctional protein with protease and helicase activities that are essential for virus replication. In this study, we used a combination of biochemical and genetic approaches to investigate the… read more here.
Keywords: protease; patch; activity; virus ... See more keywords
2.7 Å cryo-EM structure of rotavirus core protein VP3, a unique capping machine with a helicase activity
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DOI: 10.1126/sciadv.aay6410
Abstract: Rotavirus capping enzyme VP3 is a stable tetramer with unique RNA binding, RTPase, and RNA helicase activities. In many viruses, including rotavirus (RV), the major pathogen of infantile gastroenteritis, capping of viral messenger RNAs is… read more here.
Keywords: vp3; core; helicase activity; rotavirus ... See more keywords
Dengue Virus NS4b N-Terminus Disordered Region Interacts with NS3 Helicase C-Terminal Subdomain to Enhance Helicase Activity
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DOI: 10.3390/v14081712
Abstract: Dengue virus replicates its single-stranded RNA genome in membrane-bound complexes formed on the endoplasmic reticulum, where viral non-structural proteins (NS) and RNA co-localize. The NS proteins interact with one another and with the host proteins.… read more here.
Keywords: helicase activity; interaction; ns3 helicase; region ... See more keywords