Single Molecule FRET Studies on the Mechanism of ATP-Dependent RNA Unwinding by Dead-Box Helicases: An RNA-Induced Movement of the RNA Binding Domain of YxiN Regulates Unwinding by the Helicase Core
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.934
Abstract: DEAD-box proteins catalyze the ATP-dependent unwinding of RNA duplexes. Their common helicase core, formed by two RecA-like domains, is typically flanked by additional domains that modulate helicase function by hitherto unidentified mechanisms. To understand the… read more here.
Keywords: rna; rna binding; dead box; helicase core ... See more keywords
Structure of the helicase core of Werner helicase, a key target in microsatellite instability cancers
Sign Up to like & getrecommendations! Published in 2020 at "Life Science Alliance"
DOI: 10.26508/lsa.202000795
Abstract: WRN is a key drug target for cancers with microsatellite instability. A crystal structure of the helicase domain of WRN identifies its unique features and provides a basis for structure-guided design of inhibitors. Loss of… read more here.
Keywords: microsatellite instability; target; helicase; structure ... See more keywords