A scalable framework for the discovery of functional helicase substrates and helicase-driven regulatory switches
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DOI: 10.1073/pnas.2209608119
Abstract: Significance Helicases are ubiquitous NTP-dependent enzymes that disrupt nucleic acid (NA) helices and NA–protein interactions. Despite the implication of helicases in many cellular processes and diseases, their target repertoires and determinants of functional specialization often… read more here.
Keywords: framework discovery; helicase substrates; scalable framework; functional helicase ... See more keywords