Design, synthesis, and biological evaluation of stable β6.3-Helices: Discovery of non-hemolytic antibacterial peptides.
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DOI: 10.1016/j.ejmech.2018.02.057
Abstract: Gramicidin A, a topical antibiotic made from alternating L and D amino acids, is characterized by its wide central pore; upon insertion into membranes, it forms channels that disrupts ion gradients. We present helical peptidomimetics… read more here.
Keywords: design synthesis; biological evaluation; evaluation stable; helices discovery ... See more keywords