α-Helices Propagating from Stable Nucleators Exhibit Unconventional Thermal Folding.
Sign Up to like & getrecommendations! Published in 2021 at "FEBS letters"
DOI: 10.1002/1873-3468.14216
Abstract: Although the effect of thermal perturbations on protein structure has long been modelled in helical peptides, several details, such as the relation between the thermal stabilities of the propagating and nucleating segments of helices, remain elusive. We had… read more here.
Keywords: unconventional thermal; helix; helices propagating; propagating stable ... See more keywords
Solvent-dependent helix inversion in optically active poly(diphenylacetylene)s and their chiral recognition abilities as chiral stationary phases for high-performance liquid chromatography.
Sign Up to like & getrecommendations! Published in 2022 at "Chirality"
DOI: 10.1002/chir.23416
Abstract: We report the first example of solvent-dependent helix inversion in poly(diphenylacetylene) (PDPA) derivatives. Asymmetrically substituted PDPAs bearing optically active substituents linked through amide bonds formed preferred-handed helical conformations because of the optically active substituents in… read more here.
Keywords: dependent helix; solvent dependent; optically active; helix inversion ... See more keywords
Increase in CO 2 concentration could alter the response of Hedera helix to climate change
Sign Up to like & getrecommendations! Published in 2018 at "Ecology and Evolution"
DOI: 10.1002/ece3.4388
Abstract: Abstract Increasing CO 2 concentration ([CO 2]) is likely to affect future species distributions, in interaction with other climate change drivers. However, current modeling approaches still seldom consider interactions between climatic factors and the importance… read more here.
Keywords: concentration; hedera helix; climate change; helix ... See more keywords
Heterogeneity in winged helix‐turn‐helix and substrate DNA interactions: Insights from theory and experiments
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.30369
Abstract: Specific interactions between transcription factors (TFs) and substrate DNA constitute the fundamental basis of gene expression. Unlike in TFs like basic helix‐loop‐helix or basic leucine zippers, prediction of substrate DNA is extremely challenging for helix‐turn‐helix… read more here.
Keywords: heterogeneity; helix turn; dna; substrate dna ... See more keywords
A novel role of helix‐loop‐helix transcriptional factor Bhlhe40 in osteoclast activation
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30844
Abstract: The basic helix‐loop‐helix transcriptional factor, Bhlhe40 has been shown as a crucial regulator of immune response, tumorigenesis, and circadian rhythms. We identified Bhlhe40 as a possible regulator of osteoclast differentiation and function by shRNA library… read more here.
Keywords: bhlhe40; loop helix; bone; helix loop ... See more keywords
Analysis of α-helix unfolding in the pine nut peptide Lys-Cys-His-Lys-Pro induced by pulsed electric field.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the science of food and agriculture"
DOI: 10.1002/jsfa.8273
Abstract: BACKGROUND A variety of analytical techniques were applied to explore the effects of pulsed electric field (PEF) on α-helix structural changes in the novel antioxidant peptide Lys-Cys-His-Lys-Pro (KCHKP, 611.76 Da). RESULTS The relative α-helix content of… read more here.
Keywords: pulsed electric; field; lys cys; peptide lys ... See more keywords
Not as easy as π: An insertional residue does not explain the π‐helix gain‐of‐function in two‐component FMN reductases
Sign Up to like & getrecommendations! Published in 2019 at "Protein Science"
DOI: 10.1002/pro.3504
Abstract: The π‐helix located at the tetramer interface of two‐component FMN‐dependent reductases contributes to the structural divergence from canonical FMN‐bound reductases within the NADPH:FMN reductase family. The π‐helix in the SsuE FMN‐dependent reductase of the alkanesulfonate… read more here.
Keywords: reductase; insertional residue; fmn; helix ... See more keywords
Modulating long‐range energetics via helix stabilization: A case study using T4 lysozyme
Sign Up to like & getrecommendations! Published in 2018 at "Protein Science"
DOI: 10.1002/pro.3521
Abstract: Cooperative protein folding requires distant regions of a protein to interact and provide mutual stabilization. The mechanism of this long‐distance coupling remains poorly understood. Here, we use T4 lysozyme (T4L*) as a model to investigate… read more here.
Keywords: terminal subdomain; helix stabilization; long range; helix ... See more keywords
Tcf12, A Member of Basic Helix‐Loop‐Helix Transcription Factors, Mediates Bone Marrow Mesenchymal Stem Cell Osteogenic Differentiation In Vitro and In Vivo
Sign Up to like & getrecommendations! Published in 2017 at "STEM CELLS"
DOI: 10.1002/stem.2491
Abstract: Several basic Helix‐Loop‐Helix transcription factors have recently been identified to regulate mesenchymal stem cell (MSC) differentiation. In the present study, Tcf12 was investigated for its involvement in the osteoblastic cell commitment of MSCs. Tcf12 was… read more here.
Keywords: transcription; bone; differentiation; helix ... See more keywords
Assessment of melamine-coated MDF surface finish after peripheral milling under different cutting conditions
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Wood and Wood Products"
DOI: 10.1007/s00107-019-01413-y
Abstract: Milling is a machining process that is widely used in the furniture industry, since a good quality surface finish is essential. Produced MDF parts usually have aesthetic importance that is affected by poor surface finish… read more here.
Keywords: peripheral milling; surface; helix; melamine coated ... See more keywords
Conformational changes, from β-strand to α-helix, of the fatty acid-binding protein ReP1-NCXSQ in anionic lipid membranes: dependence with the vesicle curvature
Sign Up to like & getrecommendations! Published in 2017 at "European Biophysics Journal"
DOI: 10.1007/s00249-017-1243-5
Abstract: We studied the conformational changes of the fatty acid-binding protein ReP1-NCXSQ in the interface of anionic lipid membranes. ReP1-NCXSQ is an acidic protein that regulates the activity of the Na+/Ca2+ exchanger in squid axon. The… read more here.
Keywords: protein; rep1 ncxsq; fatty acid; acid binding ... See more keywords