A novel role of helix‐loop‐helix transcriptional factor Bhlhe40 in osteoclast activation
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30844
Abstract: The basic helix‐loop‐helix transcriptional factor, Bhlhe40 has been shown as a crucial regulator of immune response, tumorigenesis, and circadian rhythms. We identified Bhlhe40 as a possible regulator of osteoclast differentiation and function by shRNA library… read more here.
Keywords: bhlhe40; loop helix; bone; helix loop ... See more keywords
Genome-wide identification, classification, and functional analysis of the basic helix–loop–helix transcription factors in the cattle, Bos Taurus
Sign Up to like & getrecommendations! Published in 2017 at "Mammalian Genome"
DOI: 10.1007/s00335-017-9683-x
Abstract: The basic helix–loop–helix (bHLH) transcription factors (TFs) form a huge superfamily and play crucial roles in many essential developmental, genetic, and physiological–biochemical processes of eukaryotes. In total, 109 putative bHLH TFs were identified and categorized… read more here.
Keywords: bhlh tfs; loop helix; helix loop; helix ... See more keywords
Loss of the basic helix-loop-helix transcription factor Bhlhe41 induces cell death and impairs neurite outgrowth in Neuro2a cells
Sign Up to like & getrecommendations! Published in 2018 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-018-3383-z
Abstract: The basic helix-loop-helix (bHLH) superfamily of transcription factors have been implicated in a wide range of cellular functions such as proliferation, differentiation, tumorigenesis, and circadian rhythms. In a previous siRNA-based screen, bHLH family member e41… read more here.
Keywords: bhlhe41; loop helix; helix loop; neurite outgrowth ... See more keywords
New Class of Drug Modalities: Directed Evolution of a De Novo Designed Helix-Loop-Helix Peptide to Bind VEGF for Tumor Growth Inhibition.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical biology"
DOI: 10.1021/acschembio.1c00940
Abstract: As a small affinity molecule to serve as an alternative to antibodies, we have developed a conformationally constrained peptide with a de novo designed helix-loop-helix (HLH) scaffold. To evaluate its potential for biomedical applications, we… read more here.
Keywords: novo designed; loop helix; designed helix; growth ... See more keywords
Conversion of Helix 1 into a Loop in Prion Protein Misfolding
Sign Up to like & getrecommendations! Published in 2023 at "ACS Omega"
DOI: 10.1021/acsomega.3c00212
Abstract: Cellular prion protein PrPC consists of three α-helices, one β-sheet, and an unstructured N-terminal domain. Misfolding of this protein into the scrapie form (PrPSc) increases dramatically the β-sheet content. H1 is the most stable helix… read more here.
Keywords: prion protein; loop; helix loop; protein ... See more keywords
Helix loop-mediated isothermal amplification of nucleic acids
Sign Up to like & getrecommendations! Published in 2018 at "RSC Advances"
DOI: 10.1039/c8ra01201f
Abstract: Isothermal nucleic acid amplification has played a key role in the point of care test (POCT). In this study, a helix loop-mediated isothermal amplification (HAMP) method with high specificity, efficiency and rapidity was developed. The… read more here.
Keywords: loop mediated; mediated isothermal; helix loop; hamp ... See more keywords
Unidirectional mannitol synthesis of Acinetobacter baumannii MtlD is facilitated by the helix-loop-helix-mediated dimer formation.
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2107994119
Abstract: SignificanceMannitol biosynthesis is essential for Acinetobacter baumannii to cope with osmotic stress. Currently, only Pseudomonas putida, Acinetobacter baylyi, and A. baumannii are able to de novo synthesize mannitol by a structurally unique bifunctional mannitol-1-phosphate dehydrogenase/phosphatase… read more here.
Keywords: acinetobacter baumannii; mannitol; helix loop; helix ... See more keywords
Identification of basic helix-loop-helix transcription factors reveals candidate genes involved in pathogenicity of Fusarium pseudograminearum
Sign Up to like & getrecommendations! Published in 2019 at "Canadian Journal of Plant Pathology"
DOI: 10.1080/07060661.2018.1564941
Abstract: Abstract The basic helix-loop-helix (bHLH) transcriptional regulatory proteins are key players in a wide array of developmental processes and abiotic stress responses. The bHLH domain has been identified and functionally characterized from fungi to humans.… read more here.
Keywords: loop helix; helix loop; pseudograminearum; fusarium pseudograminearum ... See more keywords
Dissecting the Role of a Basic Helix-Loop-Helix Transcription Factor, SlbHLH22, Under Salt and Drought Stresses in Transgenic Solanum lycopersicum L.
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2019.00734
Abstract: Environmental stresses, such as temperature, heavy metals, drought, cold, and microbial infections adversely damage various aspects of plant growth and development. Salinity and drought are among major hazardous factors, which adversity affects plant growth and… read more here.
Keywords: drought; plant; helix loop; loop helix ... See more keywords
The Recombinant Inhibitor of DNA Binding Id2 Forms Multimeric Structures via the Helix-Loop-Helix Domain and the Nuclear Export Signal
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms19041105
Abstract: The inhibitor of DNA binding and cell differentiation 2 (Id2) is a helix-loop-helix (HLH) protein that acts as negative dominant regulator of basic-HLH transcription factors during development and in cancer. The structural properties of Id2… read more here.
Keywords: loop helix; helix loop; helix; dna binding ... See more keywords
Homodimeric and Heterodimeric Interactions among Vertebrate Basic Helix–Loop–Helix Transcription Factors
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms222312855
Abstract: The basic helix–loop–helix transcription factor (bHLH TF) family is involved in tissue development, cell differentiation, and disease. These factors have transcriptionally positive, negative, and inactive functions by combining dimeric interactions among family members. The best… read more here.
Keywords: helix transcription; loop helix; basic helix; helix ... See more keywords