Coupling of HSP72 α-Helix Subdomains by the Unexpected Irreversible Targeting of Lysine-56 over Cysteine-17; Coevolution of Covalent Bonding
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DOI: 10.3390/molecules25184239
Abstract: Covalent inhibition has recently gained a resurgence of interest in several drug discovery areas. The expansion of this approach is based on evidence elucidating the selectivity and potency of covalent inhibitors when bound to particular… read more here.
Keywords: hsp72 helix; covalent inhibition; helix subdomains; covalent ... See more keywords