Hemagglutinin Functionalized Liposomal Vaccines Enhance Germinal Center and Follicular Helper T Cell Immunity
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DOI: 10.1002/adhm.202002142
Abstract: Abstract Despite remarkable successes of immunization in protecting public health, safe and effective vaccines against a number of life‐threatening pathogens such as HIV, ebola, influenza, and SARS‐CoV‐2 remain urgently needed. Subunit vaccines can avoid potential… read more here.
Keywords: cell; follicular helper; liposomal vaccines; helper cell ... See more keywords
MicroRNA 182 promotes T helper 1 cell by repressing hypoxia induced factor 1 alpha in experimental autoimmune encephalomyelitis
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DOI: 10.1002/eji.201948111
Abstract: MicroRNA 182 is important for the clonal expansion of CD4+ T cells (Th) following IL‐2 stimulation and is a potential therapeutic target for autoimmune diseases. In the present study, we investigated the role of microRNA… read more here.
Keywords: autoimmune encephalomyelitis; microrna 182; helper cell; cd4 ... See more keywords
T helper cell subsets: diversification of the field.
Sign Up to like & getrecommendations! Published in 2023 at "European journal of immunology"
DOI: 10.1002/eji.202250218
Abstract: Polarized T helper cell (Th cell) responses are important determinants of host protection. Th cell subsets tailor their functional repertoire of cytokines to their cognate antigens to efficiently contribute to their clearance. In contrast, in… read more here.
Keywords: cell; helper cell; cell subsets; subsets diversification ... See more keywords
Iron deprivation restrains the differentiation and pathogenicity of T helper 17 cell
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.3ma0821-015r
Abstract: Iron plays a critical role in immune responses. However, its role in T helper cell differentiation and function remains poorly understood. In this study, it is shown that the restraint of iron availability through blocking… read more here.
Keywords: helper cell; differentiation; iron; differentiation pathogenicity ... See more keywords
RETRACTED ARTICLE: Interleukin-33 promotes helper T cell type-2/17 inflammation in children with allergic rhinitis
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DOI: 10.1007/s00405-017-4807-1
Abstract: The authors have retracted this article because of significant overlap with a previously published article [1]. All authors agree with this retraction. The online version of this article contains the full text of the retracted… read more here.
Keywords: interleukin promotes; article; retracted article; promotes helper ... See more keywords
T helper cell trafficking in autoimmune kidney diseases.
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DOI: 10.1007/s00441-020-03403-6
Abstract: CD4+ T cells are key drivers of autoimmune diseases, including crescentic GN. Many effector mechanisms employed by T cells to mediate renal damage and repair, such as local cytokine production, depend on their presence at… read more here.
Keywords: cell trafficking; trafficking autoimmune; cell; autoimmune kidney ... See more keywords
Depression and suicidality: A link to premature T helper cell aging and increased Th17 cells
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DOI: 10.1016/j.bbi.2020.02.005
Abstract: BACKGROUND Previous research has demonstrated a strong link between immune system abnormalities and Major Depressive Disorder (MDD). High suicide risk is a major complication of MDD and has recently been linked to strong (neuro-)immune alterations,… read more here.
Keywords: risk; memory helper; cell; th17 ... See more keywords
Diverse functions of miR-17-92 cluster microRNAs in T helper cells.
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DOI: 10.1016/j.canlet.2018.02.035
Abstract: T helper (Th) cells are critically involved in adaptive immune responses against various pathogens. In contrast, dysregulated T helper cell responses are associated with a variety of diseases, including autoimmunity, allergies, and cancer. Differentiation of… read more here.
Keywords: cell; cluster; mir cluster; helper cells ... See more keywords
Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses
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DOI: 10.1016/j.immuni.2021.11.001
Abstract: Adjuvants are critical for improving the quality and magnitude of adaptive immune responses to vaccination. Lipid nanoparticle (LNP)-encapsulated nucleoside-modified mRNA vaccines have shown great efficacy against SARS-CoV-2, but the mechanism of action of this vaccine… read more here.
Keywords: mrna protein; protein subunit; helper cell; follicular helper ... See more keywords
T helper cell subpopulations repertoire in peripheral blood and its correlation with sex of newly diagnosed arthritis patients: A gender based study.
Sign Up to like & getrecommendations! Published in 2019 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2019.105675
Abstract: Rheumatoid arthritis (RA) is an inflammatory autoimmune disorder. Autoreactive T cells play a very significant role in the pathogenesis of RA. However, the exact mechanisms of disease severity and pathogenesis are poorly understood. We attempted… read more here.
Keywords: cell; newly diagnosed; peripheral blood; disease severity ... See more keywords
Granuloma annulare skin profile shows activation of T-helper cell type 1, T-helper cell type 2, and Janus kinase pathways
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DOI: 10.1016/j.jaad.2019.12.028
Abstract: Background Granuloma annulare (GA) is an inflammatory skin disorder. Localized GA is often self-resolving, but generalized GA is often recalcitrant to treatments. There are no targeted treatments for GA, largely due to lack of mechanistic… read more here.
Keywords: janus kinase; helper cell; cell type;