Gene therapy with helper-dependent adenoviral vectors: lessons from studies in large animal models
Sign Up to like & getrecommendations! Published in 2017 at "Virus Genes"
DOI: 10.1007/s11262-017-1471-x
Abstract: Helper-dependent adenoviral vectors (HDAd) are deleted of all viral genes and they can efficiently transduce a wide variety of dividing and non-dividing cells to mediate high transgene expression levels. Unlike early generation adenoviral vectors, the… read more here.
Keywords: large animal; gene therapy; adenoviral vectors; dependent adenoviral ... See more keywords
Ultralow-dose binary oncolytic/helper-dependent adenovirus promotes antitumor activity in preclinical and clinical studies
Sign Up to like & getrecommendations! Published in 2023 at "Science Advances"
DOI: 10.1126/sciadv.ade6790
Abstract: We show that a binary oncolytic/helper-dependent adenovirus (CAdVEC) that both lyses tumor cells and locally expresses the proinflammatory cytokine IL-12 and PD-L1 blocking antibody has potent antitumor activity in humanized mouse models. On the basis… read more here.
Keywords: helper dependent; oncolytic helper; antitumor activity; binary oncolytic ... See more keywords