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   Articles with "helq" as a keyword



Interaction of human HelQ with DNA polymerase delta halts DNA synthesis and stimulates DNA single-strand annealing

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recommendations! Published in 2023 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkad032

Abstract: Abstract DNA strand breaks are repaired by DNA synthesis from an exposed DNA end paired with a homologous DNA template. DNA polymerase delta (Pol δ) catalyses DNA synthesis in multiple eukaryotic DNA break repair pathways… read more here.

Keywords: dna synthesis; dna; strand annealing; helq ... See more keywords

The human HELQ helicase and XRN2 exoribonuclease cooperate in R-loop resolution

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recommendations! Published in 2025 at "Open Biology"

DOI: 10.1098/rsob.240112

Abstract: The human HELQ helicase is a superfamily 2, 3′-5 helicase homologous to POLQ and RNA helicases of the Ski2-like subfamily. It is involved in diverse aspects of DNA repair and is an emerging prognosis biomarker… read more here.

Keywords: helq helicase; helq; loop resolution; helicase ... See more keywords

Division of Labor by the HELQ, BLM, and FANCM Helicases during Homologous Recombination Repair in Drosophila melanogaster

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recommendations! Published in 2022 at "Genes"

DOI: 10.3390/genes13030474

Abstract: Repair of DNA double-strand breaks by homologous recombination (HR) requires a carefully orchestrated sequence of events involving many proteins. One type of HR, synthesis-dependent strand annealing (SDSA), proceeds via the formation of a displacement loop… read more here.

Keywords: fancm; blm; helq; homologous recombination ... See more keywords

A Human Homozygous HELQ Missense Variant Does Not Cause Premature Ovarian Insufficiency in a Mouse Model

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recommendations! Published in 2024 at "Genes"

DOI: 10.3390/genes15030333

Abstract: Disruption of meiosis and DNA repair genes is associated with female fertility disorders like premature ovarian insufficiency (POI). In this study, we identified a homozygous missense variant in the HELQ gene (c.596 A>C; p.Gln199Pro) through… read more here.

Keywords: missense variant; helq; variant; mouse model ... See more keywords