Hemagglutinin-based DNA vaccines containing trimeric self-assembling nanoparticles confer protection against influenza.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of leukocyte biology"
DOI: 10.1002/jlb.6a1021-535r
Abstract: Influenza viruses continue to threaten public health, and currently available vaccines provide insufficient immunity against seasonal and pandemic influenza. The use of recombinant trimeric hemagglutinin (HA) as an Ag provides an attractive alternative to current… read more here.
Keywords: protection; dna; vaccine; influenza ... See more keywords
Inhibitory effects of azithromycin on the adherence ability of Porphyromonas gingivalis.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of periodontology"
DOI: 10.1002/jper.18-0559
Abstract: BACKGROUND Porphyromonas gingivalis is a major pathogen and has a high detection rate in periodontal disease. Fimbriae and hemagglutinin are expressed by P. gingivalis, and these play an important role in the adherence of the… read more here.
Keywords: porphyromonas gingivalis; mics azithromycin; sub mics; adherence ... See more keywords
Influenza Hemifusion Phenotype Depends on Membrane Context: Differences in Cell-Cell and Virus-Cell Fusion.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2018.01.006
Abstract: Influenza viral entry into the host cell cytoplasm is accomplished by a process of membrane fusion mediated by the viral hemagglutinin protein. Hemagglutinin acts in a pH-triggered fashion, inserting a short fusion peptide into the… read more here.
Keywords: phenotype; hemifusion phenotype; hemagglutinin; fusion ... See more keywords
H7 virus-like particles assembled by hemagglutinin containing H3N2 transmembrane domain and M1 induce broad homologous and heterologous protection in mice
Sign Up to like & getrecommendations! Published in 2018 at "Vaccine"
DOI: 10.1016/j.vaccine.2018.07.004
Abstract: Abstract Influenza A H7N9 virus has caused five outbreak waves of human infections in China since 2013 and posed a dual challenge to public health and poultry industry. There is an urgent need to develop… read more here.
Keywords: virus like; transmembrane domain; hemagglutinin; like particles ... See more keywords
Stability of HA2 Prefusion Structure and pH-Induced Conformational Changes in the HA2 Domain of H3N2 Hemagglutinin.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemistry"
DOI: 10.1021/acs.biochem.1c00551
Abstract: Influenza hemagglutinin is the fusion protein that mediates fusion of the viral and host membranes through a large conformational change upon acidification in the developing endosome. The "spring-loaded" model has long been used to describe… read more here.
Keywords: change; prefusion; conformation; hemagglutinin ... See more keywords
Cross-lineage protection by human antibodies binding the influenza B hemagglutinin
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-018-08165-y
Abstract: Influenza B viruses (IBV) drive a significant proportion of influenza-related hospitalisations yet are understudied compared to influenza A. Current vaccines target the head of the viral hemagglutinin (HA) which undergoes rapid mutation, significantly reducing vaccine… read more here.
Keywords: protection; ibv; influenza; cross ... See more keywords
Conformational modulation of influenza virus hemagglutinin: characterization and in vivo efficacy of monomeric form
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-08021-x
Abstract: Mutational changes that mostly occur at the head region of hemagglutinin (HA) lead to the emergence of new epidemic influenza viruses, whereas HA antigens have been modified to generate broadly neutralizing antibodies toward highly conserved… read more here.
Keywords: conformational modulation; influenza; monomeric form; hemagglutinin ... See more keywords
Reversible structural changes in the influenza hemagglutinin precursor at membrane fusion pH
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2208011119
Abstract: Significance Hemagglutinin (HA) is the receptor binding and membrane fusion glycoprotein of influenza virus. Like other virus fusion glycoproteins such as those of HIV and Ebola, HA is synthesized as a precursor (HA0) that requires… read more here.
Keywords: reversible structural; fusion; membrane fusion; hemagglutinin ... See more keywords
Human matriptase/ST 14 proteolytically cleaves H7N9 hemagglutinin and facilitates the activation of influenza A/Shanghai/2/2013 virus in cell culture
Sign Up to like & getrecommendations! Published in 2019 at "Influenza and Other Respiratory Viruses"
DOI: 10.1111/irv.12707
Abstract: Influenza is a zoonotic disease that infects millions of people each year resulting in hundreds of thousands of deaths, and in turn devastating pandemics. Influenza is caused by influenza viruses, including influenza A virus (IAV).… read more here.
Keywords: influenza; hemagglutinin; human matriptase; matriptase proteolytically ... See more keywords
Differential Recognition of Computationally Optimized H3 Hemagglutinin Influenza Vaccine Candidates by Human Antibodies
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Virology"
DOI: 10.1128/jvi.00896-22
Abstract: Vaccine development for circulating influenza viruses, particularly for the H3N2 subtype, remains challenging due to consistent antigenic drift. Computationally optimized broadly reactive antigen (COBRA) technology has proven effective for broadening influenza hemagglutinin (HA)-elicited antibody responses… read more here.
Keywords: recognition; computationally optimized; hemagglutinin; tj5 ... See more keywords
Antigenic sites in influenza H1 hemagglutinin display species-specific immunodominance
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Investigation"
DOI: 10.1172/jci122895
Abstract: Hemagglutination inhibition (HI) titers are a major correlate of protection for influenza-related illness. The influenza virus hemagglutinin possesses antigenic sites that are the targets of HI active antibodies. Here, a panel of mutant viruses each… read more here.
Keywords: immunodominance; antigenic sites; species specific; hemagglutinin ... See more keywords