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   Articles with "hemagglutinin" as a keyword



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Hemagglutinin-based DNA vaccines containing trimeric self-assembling nanoparticles confer protection against influenza.

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recommendations! Published in 2022 at "Journal of leukocyte biology"

DOI: 10.1002/jlb.6a1021-535r

Abstract: Influenza viruses continue to threaten public health, and currently available vaccines provide insufficient immunity against seasonal and pandemic influenza. The use of recombinant trimeric hemagglutinin (HA) as an Ag provides an attractive alternative to current… read more here.

Keywords: protection; dna; vaccine; influenza ... See more keywords

Inhibitory effects of azithromycin on the adherence ability of Porphyromonas gingivalis.

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recommendations! Published in 2019 at "Journal of periodontology"

DOI: 10.1002/jper.18-0559

Abstract: BACKGROUND Porphyromonas gingivalis is a major pathogen and has a high detection rate in periodontal disease. Fimbriae and hemagglutinin are expressed by P. gingivalis, and these play an important role in the adherence of the… read more here.

Keywords: porphyromonas gingivalis; mics azithromycin; sub mics; adherence ... See more keywords

Influenza Hemifusion Phenotype Depends on Membrane Context: Differences in Cell-Cell and Virus-Cell Fusion.

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recommendations! Published in 2018 at "Journal of molecular biology"

DOI: 10.1016/j.jmb.2018.01.006

Abstract: Influenza viral entry into the host cell cytoplasm is accomplished by a process of membrane fusion mediated by the viral hemagglutinin protein. Hemagglutinin acts in a pH-triggered fashion, inserting a short fusion peptide into the… read more here.

Keywords: phenotype; hemifusion phenotype; hemagglutinin; fusion ... See more keywords

H7 virus-like particles assembled by hemagglutinin containing H3N2 transmembrane domain and M1 induce broad homologous and heterologous protection in mice

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recommendations! Published in 2018 at "Vaccine"

DOI: 10.1016/j.vaccine.2018.07.004

Abstract: Abstract Influenza A H7N9 virus has caused five outbreak waves of human infections in China since 2013 and posed a dual challenge to public health and poultry industry. There is an urgent need to develop… read more here.

Keywords: virus like; transmembrane domain; hemagglutinin; like particles ... See more keywords
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Stability of HA2 Prefusion Structure and pH-Induced Conformational Changes in the HA2 Domain of H3N2 Hemagglutinin.

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recommendations! Published in 2021 at "Biochemistry"

DOI: 10.1021/acs.biochem.1c00551

Abstract: Influenza hemagglutinin is the fusion protein that mediates fusion of the viral and host membranes through a large conformational change upon acidification in the developing endosome. The "spring-loaded" model has long been used to describe… read more here.

Keywords: change; prefusion; conformation; hemagglutinin ... See more keywords

Detection of Hemagglutinin H5 Influenza A Virus RNA and Model of Potential Inputs in an Urban California Sewershed

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recommendations! Published in 2025 at "Environmental Science & Technology"

DOI: 10.1021/acs.est.4c14792

Abstract: In 2024, the highly pathogenic avian influenza A H5N1 caused outbreaks in wild birds, poultry, cows, and other mammals in the United States with 61 human cases also reported by the CDC. Detection of influenza… read more here.

Keywords: detection; california sewershed; influenza; urban california ... See more keywords

Cross-lineage protection by human antibodies binding the influenza B hemagglutinin

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recommendations! Published in 2019 at "Nature Communications"

DOI: 10.1038/s41467-018-08165-y

Abstract: Influenza B viruses (IBV) drive a significant proportion of influenza-related hospitalisations yet are understudied compared to influenza A. Current vaccines target the head of the viral hemagglutinin (HA) which undergoes rapid mutation, significantly reducing vaccine… read more here.

Keywords: protection; ibv; influenza; cross ... See more keywords

Epistasis mediates the evolution of the receptor binding mode in recent human H3N2 hemagglutinin

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recommendations! Published in 2024 at "Nature Communications"

DOI: 10.1038/s41467-024-49487-4

Abstract: The receptor-binding site of influenza A virus hemagglutinin partially overlaps with major antigenic sites and constantly evolves. In this study, we observe that mutations G186D and D190N in the hemagglutinin receptor-binding site have coevolved in… read more here.

Keywords: receptor; human h3n2; hemagglutinin; receptor binding ... See more keywords

Conformational modulation of influenza virus hemagglutinin: characterization and in vivo efficacy of monomeric form

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recommendations! Published in 2017 at "Scientific Reports"

DOI: 10.1038/s41598-017-08021-x

Abstract: Mutational changes that mostly occur at the head region of hemagglutinin (HA) lead to the emergence of new epidemic influenza viruses, whereas HA antigens have been modified to generate broadly neutralizing antibodies toward highly conserved… read more here.

Keywords: conformational modulation; influenza; monomeric form; hemagglutinin ... See more keywords

Reversible structural changes in the influenza hemagglutinin precursor at membrane fusion pH

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recommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2208011119

Abstract: Significance Hemagglutinin (HA) is the receptor binding and membrane fusion glycoprotein of influenza virus. Like other virus fusion glycoproteins such as those of HIV and Ebola, HA is synthesized as a precursor (HA0) that requires… read more here.

Keywords: reversible structural; fusion; membrane fusion; hemagglutinin ... See more keywords

Intranasal hemagglutinin protein boosters induce protective mucosal immunity against influenza A viruses in mice

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recommendations! Published in 2025 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2422171122

Abstract: Significance While current influenza vaccines protect against severe diseases, shortcomings include limited cross-protection, short-lived immunity, and vaccine hesitancy concerns including the fear of needles. We describe a nasal booster approach, Prime and hemagglutinin (HA), with… read more here.

Keywords: mucosal; immunity; influenza; hemagglutinin protein ... See more keywords