The Kinetics of β-Hematin Crystallization Measured by Depolarized Light Scattering.
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DOI: 10.1002/smll.201802295
Abstract: Malaria is caused by Plasmodium sp. parasites transmitted by infected female Anopheles sp. mosquitoes. The survival of the parasites in the host relies on detoxifying free heme by biocrystallization into insoluble crystals called hemozoin. This… read more here.
Keywords: crystallization measured; kinetics hematin; hematin crystallization; light scattering ... See more keywords
Antimalarial Activity of Highly Coordinative Fused Heterocycles Targeting β-Hematin Crystallization
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DOI: 10.1021/acsomega.1c05393
Abstract: The β-hematin formation is a unique process adopted by Plasmodium sp. to detoxify free heme and represents a validated target to design new effective antimalarials. Most of the β-hematin inhibitors are mainly based on 4-aminoquinolines,… read more here.
Keywords: hematin crystallization; highly coordinative; activity; crystallization ... See more keywords