Prolonged hematologic toxicity following treatment with chimeric antigen receptor T cells in patients with hematologic malignancies
Sign Up to like & getrecommendations! Published in 2021 at "American Journal of Hematology"
DOI: 10.1002/ajh.26113
Abstract: Chimeric antigen receptor T‐cell therapy (CAR T) is a novel intervention for relapsed/refractory diffuse large B‐cell lymphoma (R/R DLBCL) and other hematologic malignancies. However, it is associated with prolonged hematologic toxicity (PHT) that is unpredictable… read more here.
Keywords: hematologic toxicity; cell therapy; prolonged hematologic; toxicity ... See more keywords
Hematologic toxicity profile and efficacy of [225Ac]Ac-PSMA-617 α-radioligand therapy of patients with extensive skeletal metastases of castration-resistant prostate cancer
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s00259-022-05778-w
Abstract: Actinium-225-labeled prostate-specific membrane antigen ([225Ac]Ac-PSMA-617) is safe and effective in the treatment of metastatic castration-resistant prostate cancer (mCRPC). No study has specifically assessed its safety in patients with extensive skeletal metastases of mCRPC. We aimed… read more here.
Keywords: toxicity; hematologic toxicity; treatment; skeletal metastases ... See more keywords
The Impact of Pelvic Nodal Radiotherapy on Hematologic Toxicity: A Systematic Review with Focus on Leukopenia, Lymphopenia and Future Perspectives in Prostate Cancer Treatment.
Sign Up to like & getrecommendations! Published in 2021 at "Critical reviews in oncology/hematology"
DOI: 10.1016/j.critrevonc.2021.103497
Abstract: INTRODUCTION Hematologic toxicity (HT), particularly leukopenia, is a common side-effect of oncologic treatments for pelvic malignancies. Pelvic nodal radiotherapy (PNRT) has been associated with HT development mainly through incidental bone marrow (BM) irradiation; however, several… read more here.
Keywords: hematologic toxicity; radiotherapy; prostate cancer; cancer treatment ... See more keywords
114. Pelvic bone marrow dosimetric parameters analysis relating to hematologic toxicity in gynecological tumors patients treated with volumetric modulated arc therapy
Sign Up to like & getrecommendations! Published in 2018 at "Physica Medica"
DOI: 10.1016/j.ejmp.2018.04.125
Abstract: Purpose To test the hypothesis that the volume of pelvic bone marrow (PBM) receiving 10–20-30–40 Gy (V10-V20-V30-V40) and median dose is associated with hematologic toxicity (HT) in gynecological cancer patients treated with concurrent chemoradiotherapy. Methods and… read more here.
Keywords: hematologic toxicity; pelvic bone; bone; toxicity gynecological ... See more keywords
Hematologic toxicity in anal cancer patients during combined chemo-radiation: a radiation oncologist perspective
Sign Up to like & getrecommendations! Published in 2017 at "Expert Review of Anticancer Therapy"
DOI: 10.1080/14737140.2017.1288104
Abstract: ABSTRACT Introduction: Hematologic toxicity is an important side effect occurring in patients affected with anal cancer, undergoing combined radio-chemotherapy, with consistent clinical meaningfulness. Areas covered: Since more than a half of bone marrow is comprised… read more here.
Keywords: anal cancer; bone marrow; hematologic toxicity; radiation ... See more keywords
Prevalence of hematologic toxicity from copperhead envenomation: an observational study
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Toxicology"
DOI: 10.1080/15563650.2019.1644346
Abstract: Abstract Background: Copperhead snakes (Agkistrodon contortrix) are considered as the least toxic of the North American pit vipers. The reported incidence of coagulopathy from copperhead envenomation is variable, possibly secondary to regional variation in subspecies… read more here.
Keywords: hematologic toxicity; prevalence; study; copperhead envenomation ... See more keywords
Reducing Hematologic Toxicity With Short Course Postexposure Prophylaxis With Zidovudine for HIV-1 Exposed Infants With Low Transmission Risk.
Sign Up to like & getrecommendations! Published in 2019 at "Pediatric Infectious Disease Journal"
DOI: 10.1097/inf.0000000000002357
Abstract: Using retrospectively collected data from 383 infants born to HIV-1-infected mothers receiving antiretroviral therapy, we compared transmission rates and hematologic toxicity between infants receiving 2-week (short course) versus longer duration zidovudine postexposure prophylaxis. Short course… read more here.
Keywords: hematologic toxicity; postexposure prophylaxis; short course; transmission ... See more keywords
Clonal Hematopoiesis and Inflammation Predict Hematologic Toxicity and Secondary Myeloid Malignancies after B-Cell Maturation Antigen–Directed Chimeric Antigen Receptor T-cell Therapy
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DOI: 10.1158/1078-0432.ccr-25-1587
Abstract: Abstract Purpose: Chimeric antigen receptor T cells (CAR-T) have demonstrated remarkable efficacy in multiple myeloma, but prolonged hematologic toxicity remains a common adverse event, and secondary myeloid malignancies are a significant safety concern. Experimental Design:… read more here.
Keywords: cell maturation; secondary myeloid; hematologic toxicity; antigen ... See more keywords
Abstract LB207: Continuous subcutaneous lenalidomide delivery improves the therapeutic index and avoids drug-related grade 3/4 hematologic toxicity in patients with relapsed/refractory multiple myeloma
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-lb207
Abstract: In a multiple myeloma mouse model (MM), we determined that subcutaneous (SC) continuous lenalidomide (Len) delivery demonstrated superior tolerability and efficacy to the active control Len given by daily i.p. over a 28 day cycle.… read more here.
Keywords: relapsed refractory; drug related; hematologic toxicity; therapeutic index ... See more keywords
Lutetium-177 dotatate PRRT in GEP-NETs: Hematologic toxicity trends, recovery profiles, and discontinuation rates
Sign Up to like & getrecommendations! Published in 2025 at "Blood"
DOI: 10.1182/blood-2025-6698
Abstract: Introduction: Lutetium-177 DOTATATE peptide receptor radionuclide therapy (PRRT) is an effective treatment for gastroenteropancreatic neuroendocrine tumors (GEP-NETs). While generally well tolerated, PRRT can result in hematologic toxicity ranging from mild cytopenias to therapy-related myeloid neoplasms… read more here.
Keywords: treatment; hematologic toxicity; prrt; 177 dotatate ... See more keywords
Predicting hematologic toxicity in advanced cervical cancer patients using interpretable machine learning models based on radiomics and dosimetrics
Sign Up to like & getrecommendations! Published in 2025 at "BMC Cancer"
DOI: 10.1186/s12885-025-14999-9
Abstract: Hematologic toxicity (HT) is a common and serious side effect for advanced cervical cancer patients undergoing chemoradiotherapy. Accurately predicting HT can significantly improve patient management and treatment outcomes. This study aims to develop and evaluate… read more here.
Keywords: cancer; hematologic toxicity; cancer patients; cervical cancer ... See more keywords