Clinical utility of ABCB1 genotyping for preventing toxicity in treatment with irinotecan
Sign Up to like & getrecommendations! Published in 2018 at "Pharmacological Research"
DOI: 10.1016/j.phrs.2018.08.026
Abstract: ABSTRACT Preventing severe irinotecan‐induced adverse reactions would allow us to offer better treatment and improve patients’ quality of life. Transporters, metabolizing enzymes, and genes involved in the folate pathway have been associated with irinotecan‐induced toxicity.… read more here.
Keywords: treatment; adverse reactions; overall toxicity; toxicity ... See more keywords
Hematological toxicities associated with linezolid therapy in adults: key findings and clinical considerations
Sign Up to like & getrecommendations! Published in 2023 at "Expert Review of Clinical Pharmacology"
DOI: 10.1080/17512433.2023.2181160
Abstract: ABSTRACT Introduction Linezolid can cause serious adverse effects including thrombocytopenia and anemia. Here, we focus specifically on linezolid-related hematological toxicity in adult patients requiring prolonged drug treatment. Areas covered We review the available evidence on… read more here.
Keywords: hematological toxicities; linezolid therapy; associated linezolid; thrombocytopenia ... See more keywords
RADT-45. EFFECT OF DIFFERENT RADIOTHERAPY TECHNIQUES ON HEMATOLOGICAL TOXICITY OF CRANIOSPINAL IRRADIATION
Sign Up to like & getrecommendations! Published in 2020 at "Neuro-oncology"
DOI: 10.1093/neuonc/noaa215.798
Abstract: To investigate the effect of different radiotherapy techniques on hematological toxicity of craniospinal irradiation. A retrospective study involving changes in hematology during craniospinal irradiation were conducted. 79 patients were divided into observation group and control… read more here.
Keywords: craniospinal irradiation; radiotherapy; group; hematological toxicity ... See more keywords
OS05.7.A Absence of severe hematological toxicity during first line treatment predicts low chance on severe toxicity during second line alkylating chemotherapy in glioblastoma
Sign Up to like & getrecommendations! Published in 2021 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noab180.023
Abstract: Glioblastoma has an infiltrative growth pattern that makes complete resection of the tumor virtually impossible. Sooner or later the tumor progresses, even after aggressive treatment with maximal safe resection, radiotherapy and/or chemotherapy. Hematological toxicity is… read more here.
Keywords: 2nd line; line; hematological toxicity; toxicity ... See more keywords
Risk Associated with Severe Hematological Toxicity in Patients with Urothelial Cancer Receiving Combination Chemotherapy of Gemcitabine and Cisplatin
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DOI: 10.1159/000508805
Abstract: Introduction: Combination chemotherapy of gemcitabine and cisplatin (GC) is the standard treatment for patients with urothelial cancer (UC). However, hematological toxicity is a major side effect of GC therapy in patients with UC. In particular,… read more here.
Keywords: chemotherapy; toxicity patients; risk factors; hematological toxicity ... See more keywords
This Is a Title: Single-Center Data Report of Clhag Regimen for R/R-AML Patients
Sign Up to like & getrecommendations! Published in 2020 at "Blood"
DOI: 10.1182/blood-2020-139708
Abstract: Objectives: To explore the synergistic effect of CLAG combination with HHT in cell experiments and to evaluate the effectiveness and safety of the CLHAG regimen for patients with relapsed/refractory acute myeloid leukemia(R/R-AML). Methods:In thecell experiments,… read more here.
Keywords: synergistic effect; clhag regimen; hematological toxicity; aml patients ... See more keywords
Safety of different amphotericin B formulations among AIDS patients with invasive fungal disease: a retrospective observational study
Sign Up to like & getrecommendations! Published in 2024 at "AIDS Research and Therapy"
DOI: 10.1186/s12981-024-00649-w
Abstract: We conducted a retrospective, observational study among acquired immune deficiency syndrome (AIDS) patients with cryptococcal meningitis or talaromycosis to assess AmB formulations-related adverse events (AEs). Total 205 eligible patients were enrolled. Of them, 139 received… read more here.
Keywords: aids patients; observational study; amb; hematological toxicity ... See more keywords
Hematological toxicity of anti-tumor antibody-drug conjugates: A retrospective pharmacovigilance study using the FDA adverse event reporting system
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DOI: 10.1371/journal.pone.0334513
Abstract: Background Although antibody-drug conjugates (ADCs) have shown significant efficacy in cancer treatment, hematotoxicity remains a serious issue. This study aims to investigate the relationship between ADCs and hematological toxicity. Methods Our study was conducted using… read more here.
Keywords: hematotoxicity; hematological toxicity; drug; antibody drug ... See more keywords
Genetic polymorphisms and platinum-induced hematological toxicity: a systematic review
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DOI: 10.3389/fphar.2024.1445328
Abstract: Background Platinum-based chemotherapy bring severe hematological toxicity that can lead to dose reduction or discontinuation of therapy. Genetic variations have been reported to influence the risk and extent of hematological toxicity; however, the results are… read more here.
Keywords: hematological toxicity; toxicity; systematic review; platinum induced ... See more keywords
In Vitro Antithrombotic, Hematological Toxicity, and Inhibitor Studies of Protocatechuic, Isovanillic, and p-Hydroxybenzoic Acids from Maclura tricuspidata (Carr.) Bur
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27113496
Abstract: In blood coagulation, circulating platelets and coagulation factors are crucial for the primary process because thrombi are generated by fibrin clotting with fibrinogen, thrombin, FXIIIa, and platelet activation. Therefore, strategies to reduce the activity of… read more here.
Keywords: inhibition; carr bur; inhibition type; hematological toxicity ... See more keywords
Cytidine deaminase 435C>T polymorphism relates to gemcitabine-platinum efficacy and hematological toxicity in Chinese non-small-cell lung cancer patients.
Sign Up to like & getrecommendations! Published in 2021 at "Neoplasma"
DOI: 10.4149/neo_2021_201116n1229
Abstract: CDA 435C>T is reported as a functional SNP but there is no relevant research on the efficacy/hematological toxicity of gemcitabine-platinum treatment in Chinese non-small-cell lung cancer (NSCLC) patients. In this study, 63 patients who received… read more here.
Keywords: toxicity; efficacy hematological; cda 435c; gemcitabine platinum ... See more keywords