Clinical Importance of Clonal Hematopoiesis in Metastatic Gastrointestinal Tract Cancers
Sign Up to like & getrecommendations! Published in 2023 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.54221
Abstract: Key Points Question To what extent is clonal hematopoiesis (CH) associated with treatment response and toxicity among patients with metastatic cancer who receive chemotherapy or immune checkpoint blockade? Findings In this cohort study of 633… read more here.
Keywords: metastatic gastrointestinal; hematopoiesis metastatic; importance clonal; clinical importance ... See more keywords
G‐CSF/GM‐CSF‐induced hematopoietic dysregulation in the progression of solid tumors
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13445
Abstract: There are two types of abnormal hematopoiesis in solid tumor occurrence and treatment: pathological hematopoiesis, and myelosuppression induced by radiotherapy and chemotherapy. In this review we primarily focus on the abnormal pathological hematopoietic differentiation in… read more here.
Keywords: csf; csf induced; csf csf; hematopoiesis ... See more keywords
The Zinc Transporter SLC39A10 Plays an Essential Role in Embryonic Hematopoiesis.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced science"
DOI: 10.1002/advs.202205345
Abstract: The role of zinc in hematopoiesis is currently unclear. Here, SLC39A10 (ZIP10) is identified as a key zinc transporter in hematopoiesis. The results show that in zebrafish, Slc39a10 is a key regulator of the response… read more here.
Keywords: zinc deficiency; zinc transporter; zinc; role ... See more keywords
Osteoblast Lineage Support of Hematopoiesis in Health and Disease
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.4678
Abstract: In mammals, hematopoiesis migrates to the bone marrow during embryogenesis coincident with the appearance of mineralized bone, where hematopoietic stem cells (HSCs) and their progeny are maintained by the surrounding microenvironment or niche, and sustain… read more here.
Keywords: health disease; hematopoiesis health; hematopoiesis; osteoblast lineage ... See more keywords
The role of cell adhesion in hematopoiesis and leukemogenesis
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28636
Abstract: The cells of the bone marrow microenvironment are emerging as important contributors and regulators of normal hematopoiesis. This microenvironment is perturbed during leukemogenesis, and evidence points toward a bidirectional communication between leukemia cells and the… read more here.
Keywords: hematopoiesis; leukemogenesis; cell adhesion; role ... See more keywords
Hhex Regulates Hematopoietic Stem Cell Self‐Renewal and Stress Hematopoiesis via Repression of Cdkn2a
Sign Up to like & getrecommendations! Published in 2017 at "STEM CELLS"
DOI: 10.1002/stem.2648
Abstract: The hematopoietically expressed homeobox transcription factor (Hhex) is important for the maturation of definitive hematopoietic progenitors and B‐cells during development. We have recently shown that in adult hematopoiesis, Hhex is dispensable for maintenance of hematopoietic… read more here.
Keywords: hematopoiesis; cdkn2a; self renewal; hematopoietic stem ... See more keywords
MicroRNAs as regulators and effectors of hematopoietic transcription factors
Sign Up to like & getrecommendations! Published in 2019 at "Wiley Interdisciplinary Reviews: RNA"
DOI: 10.1002/wrna.1537
Abstract: Hematopoiesis is a highly‐regulated development process orchestrated by lineage‐specific transcription factors that direct the generation of all mature blood cells types, including red blood cells, megakaryocytes, granulocytes, monocytes, and lymphocytes. Under homeostatic conditions, the hematopoietic… read more here.
Keywords: hematopoiesis; hematopoietic transcription; transcription; transcription factors ... See more keywords
RNA N 6-Methyladenosine Modification in Normal and Malignant Hematopoiesis.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-13-7342-8_4
Abstract: As the most abundant internal modification in eukaryotic messenger RNAs (mRNAs), N 6-methyladenosine (m6A) modification has been shown recently to posttranscriptionally regulate expression of thousands of messenger RNA (mRNA) transcripts in each mammalian cell type… read more here.
Keywords: hematopoiesis; m6a modification; rna methyladenosine; methyladenosine modification ... See more keywords
The role of ASXL1 in hematopoiesis and myeloid malignancies
Sign Up to like & getrecommendations! Published in 2019 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-019-03084-7
Abstract: Recent high-throughput genome-wide sequencing studies have identified recurrent somatic mutations in myeloid neoplasms. An epigenetic regulator, Additional sex combs-like 1 (ASXL1), is one of the most frequently mutated genes in all subtypes of myeloid malignancies.… read more here.
Keywords: role; myeloid malignancies; asxl1 mutations; hematopoiesis ... See more keywords
The vasculature niches required for hematopoiesis.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of molecular medicine"
DOI: 10.1007/s00109-021-02155-2
Abstract: Endothelial cells play a critical role in supporting postnatal hematopoiesis in the bone marrow. Unique endothelial cells, together with various perivascular cells, form different types of vascular structures, constructing a vast microvascular delivery and trafficking… read more here.
Keywords: vasculature niches; hematopoiesis; required hematopoiesis; vasculature ... See more keywords
Dynamics of hematopoiesis is disrupted by impaired hematopoietic microenvironment in a mouse model of hemophagocytic lymphohistiocytosis
Sign Up to like & getrecommendations! Published in 2020 at "Annals of Hematology"
DOI: 10.1007/s00277-020-04095-2
Abstract: Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening systemic hyperinflammatory disorder. We found recently that repeated lipopolysaccharide (LPS) treatment induces HLH-like features in senescence-accelerated mice (SAMP1/TA-1) but not in senescence-resistant control mice (SAMR1). In this study, we… read more here.
Keywords: hematopoiesis; dynamics hematopoiesis; hemophagocytic lymphohistiocytosis; factor ... See more keywords