Clonal Hematopoiesis of Indeterminate Potential and Cardiovascular Disease
Sign Up to like & getrecommendations! Published in 2020 at "Current Oncology Reports"
DOI: 10.1007/s11912-020-00955-2
Abstract: Purpose of Review The purpose of this review article is to summarize the preclinical and clinical evidence supporting the notion of clonal hematopoiesis of indeterminate potential (CHIP), highlight current knowledge gap, and provide future directions.… read more here.
Keywords: risk; clonal hematopoiesis; hematopoiesis indeterminate; chip ... See more keywords
THE ASSOCIATION OF CLONAL HEMATOPOIESIS OF INDETERMINATE POTENTIAL WITH CHRONIC ISCHEMIC HEART FAILURE
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Hematology"
DOI: 10.1016/j.exphem.2019.06.352
Abstract: Cardiovascular diseases (CVD) are one of the leading causes of death. Beside established risk factors, clonal hematopoiesis of indeterminate potential (CHIP) is associated with a higher risk of CVD. CHIP is defined as the expansion… read more here.
Keywords: chronic ischemic; ischemic heart; indeterminate potential; clonal hematopoiesis ... See more keywords
Clonal Hematopoiesis of Indeterminate Potential Reshapes Age-Related CVD: JACC Review Topic of the Week.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American College of Cardiology"
DOI: 10.1016/j.jacc.2019.05.045
Abstract: The incidence of cardiovascular diseases increases with age and is also correlated with increased inflammatory burden. Recently, human genetics provided a new paradigm linking aging, inflammation, and atherosclerotic cardiovascular disease (ASCVD). Next-generation genetic sequencing of… read more here.
Keywords: clonal hematopoiesis; age; indeterminate potential; hematopoiesis indeterminate ... See more keywords
A practical approach to curate clonal hematopoiesis of indeterminate potential in human genetic datasets
Sign Up to like & getrecommendations! Published in 2022 at "Blood"
DOI: 10.1101/2022.10.21.22281368
Abstract: Clonal hematopoiesis of indeterminate potential (CHIP) is a common form of age-related somatic mosaicism that is associated with significant morbidity and mortality. CHIP mutations can be identified in peripheral blood samples sequenced using approaches that… read more here.
Keywords: indeterminate potential; hematopoiesis indeterminate; approach; chip ... See more keywords
Defining clonal hematopoiesis of indeterminate potential: evolutionary dynamics and detection under aging and inflammation.
Sign Up to like & getrecommendations! Published in 2023 at "Cold Spring Harbor molecular case studies"
DOI: 10.1101/mcs.a006251
Abstract: Clonal hematopoiesis (CH), in which hematopoietic stem and progenitor cell (HSPC) clones and their progeny expand in the circulating blood cell population, occurs following the acquisition of somatic driver mutations. Individuals diagnosed with clonal hematopoiesis… read more here.
Keywords: indeterminate potential; hematopoiesis indeterminate; etiology; chip ... See more keywords
Mendelian randomization supports bidirectional causality between telomere length and clonal hematopoiesis of indeterminate potential
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abl6579
Abstract: Human genetic studies support an inverse causal relationship between leukocyte telomere length (LTL) and coronary artery disease (CAD), but directionally mixed effects for LTL and diverse malignancies. Clonal hematopoiesis of indeterminate potential (CHIP), characterized by… read more here.
Keywords: telomere length; cad; indeterminate potential; hematopoiesis indeterminate ... See more keywords
Clonal hematopoiesis of indeterminate potential in patients with solid tumor malignancies.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer research"
DOI: 10.1158/0008-5472.can-22-0985
Abstract: Clonal hematopoiesis of indeterminate potential (CHIP) refers to the expansion of cells of hematopoietic lineage that carry acquired somatic alterations associated with hematologic malignancies. The most commonly altered genes giving rise to CHIP are DNMT3A,… read more here.
Keywords: patients solid; indeterminate potential; hematopoiesis indeterminate; chip ... See more keywords
Clonal Hematopoiesis of Indeterminate Potential Is Associated With Coronary Microvascular Dysfunction In Early Nonobstructive Coronary Artery Disease
Sign Up to like & getrecommendations! Published in 2023 at "Arteriosclerosis, Thrombosis, and Vascular Biology"
DOI: 10.1161/atvbaha.122.318928
Abstract: Background: Clonal hematopoiesis (CH) of indeterminate potential (CHIP) is a risk factor for cardiovascular disease. The relationship between CHIP and coronary microvascular dysfunction (CMD) is unknown. The current study examines the association between CHIP and… read more here.
Keywords: adverse cardiovascular; disease; indeterminate potential; hematopoiesis indeterminate ... See more keywords
Patient perspectives on testing for clonal hematopoiesis of indeterminate potential
Sign Up to like & getrecommendations! Published in 2022 at "Blood Advances"
DOI: 10.1182/bloodadvances.2022008376
Abstract: Key Points • Many young breast cancer survivors are interested in CHIP testing, with preferences varying by risk communication and actionability.• Learning of CHIP and its associated risks may elicit significant anxiety, requiring provider awareness… read more here.
Keywords: perspectives testing; testing clonal; indeterminate potential; hematopoiesis indeterminate ... See more keywords
Clonal hematopoiesis of indeterminate potential and its impact on patient trajectories after stem cell transplantation
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DOI: 10.1371/journal.pcbi.1006913
Abstract: Clonal hematopoiesis of indeterminate potential (CHIP) is a recently identified process where older patients accumulate distinct subclones defined by recurring somatic mutations in hematopoietic stem cells. CHIP’s implications for stem cell transplantation have been harder… read more here.
Keywords: clonal hematopoiesis; cell transplantation; stem cell; transplantation ... See more keywords
Case Report: First longitudinal study of a patient with CALR positive clonal hematopoiesis of indeterminate potential developing into pre-fibrotic myelofibrosis
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2023.1176173
Abstract: Initial diagnosis of overt myeloproliferative neoplasms (MPNs) represents the juncture during clonal evolution when symptoms or complications prompt an afflicted individual to seek medical attention. In 30-40% of the MPN subgroups essential thrombocythemia (ET) and… read more here.
Keywords: calr; indeterminate potential; hematopoiesis indeterminate; case report ... See more keywords