Sensing context: Inhibitory receptors on non‐hematopoietic cells
Sign Up to like & getrecommendations! Published in 2023 at "European Journal of Immunology"
DOI: 10.1002/eji.202250306
Abstract: Similar to immune cells, non‐hematopoietic cells recognize microbial and endogenous threats. Their response to these stimuli is dependent on the environmental context. For example, intact intestinal epithelium expresses pattern recognition receptors (PRRs) but should tolerate… read more here.
Keywords: receptors non; hematopoietic cells; inhibitory receptors; non hematopoietic ... See more keywords
Repression of Primitive Erythroid Program Is Critical for the Initiation of Multi‐Lineage Hematopoiesis in Mouse Development
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.25422
Abstract: Formation of the hematopoietic cells occurs in multiple steps. The first hematopoietic cells observed during ontogeny are primitive erythrocytes, which are produced in the early yolk sac within a limited temporal window. Multi‐lineage hematopoiesis, which… read more here.
Keywords: multi lineage; cell; lineage hematopoiesis; hematopoietic cells ... See more keywords
Genome-Wide Analysis of DNA Methylation in Hematopoietic Cells: DNA Methylation Analysis by WGBS.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7142-8_9
Abstract: DNA methylation is a major epigenetic modification that regulates gene expression, genome imprinting, and development and has a role in diseases including cancer. There are various methods for whole-genome methylation profiling that differ in cost… read more here.
Keywords: genome wide; methylation; analysis; dna methylation ... See more keywords
Single-Cell Analysis Identifies Distinct Stages of Human Endothelial-to-Hematopoietic Transition.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.03.023
Abstract: During development, hematopoietic cells originate from endothelium in a process known as endothelial-to-hematopoietic transition (EHT). To study human EHT, we coupled flow cytometry and single-cell transcriptional analyses of human pluripotent stem cell-derived CD34+ cells. The… read more here.
Keywords: single cell; endothelial hematopoietic; hematopoietic transition; cell ... See more keywords
Matrix Gla protein maintains normal and malignant hematopoietic progenitor cells by interacting with bone morphogenetic protein-4
Sign Up to like & getrecommendations! Published in 2020 at "Heliyon"
DOI: 10.1016/j.heliyon.2020.e03743
Abstract: Matrix Gla protein (MGP), a modulator of the BMP-SMAD signals, inhibits arterial calcification in a Glu γ-carboxylation dependent manner but the role of MGP highly expressed in a subset of bone marrow (BM) mesenchymal stem/stromal… read more here.
Keywords: protein; bmp; normal malignant; stromal cells ... See more keywords
Immunophenotypic dissection of normal hematopoiesis.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of immunological methods"
DOI: 10.1016/j.jim.2019.112684
Abstract: Flow cytometry immunophenotyping is essential for diagnosis, classification and monitoring of clonal hematopoietic diseases, particularly of hematological malignancies and primary immunodeficiencies. Optimal use of immunophenotyping for these purposes requires detailed knowledge about the phenotypic patterns… read more here.
Keywords: phenotypic; normal hematopoiesis; hematopoietic cells; dissection normal ... See more keywords
Generation of Vascular Endothelial Cells and Hematopoietic Cells by Blastocyst Complementation
Sign Up to like & getrecommendations! Published in 2018 at "Stem Cell Reports"
DOI: 10.1016/j.stemcr.2018.08.015
Abstract: Summary In the case of organ transplantation accompanied by vascular anastomosis, major histocompatibility complex mismatched vascular endothelial cells become a target for graft rejection. Production of a rejection-free, transplantable organ, therefore, requires simultaneous generation of… read more here.
Keywords: vascular endothelial; cells hematopoietic; blastocyst complementation; endothelial cells ... See more keywords
Granulocyte-derived TNFα promotes vascular and hematopoietic regeneration in the bone marrow
Sign Up to like & getrecommendations! Published in 2018 at "Nature medicine"
DOI: 10.1038/nm.4448
Abstract: Endothelial cells are a critical component of the bone marrow (BM) stromal network, which maintains and regulates hematopoietic cells. Vascular regeneration precedes, and is necessary for, successful hematopoietic stem cell (HSC) transplantation, the only cure… read more here.
Keywords: hematopoietic regeneration; regeneration; granulocyte; hematopoietic cells ... See more keywords
Complosome as a new intracellular regulatory network in both normal and malignant hematopoiesis
Sign Up to like & getrecommendations! Published in 2025 at "Leukemia"
DOI: 10.1038/s41375-025-02613-7
Abstract: Hematopoietic cells and lymphocytes arise from a common stem cell for both lineages. This explains why similar signaling networks regulate the development and biological functions of these cells. One crucial regulatory mechanism involves interactions with… read more here.
Keywords: hematopoietic cells; network normal; network; malignant hematopoiesis ... See more keywords
Long-term engrafting multilineage hematopoietic cells differentiated from human induced pluripotent stem cells
Sign Up to like & getrecommendations! Published in 2024 at "Nature Biotechnology"
DOI: 10.1038/s41587-024-02360-7
Abstract: Hematopoietic stem cells (HSCs) derived from human induced pluripotent stem cells (iPS cells) have important biomedical applications. We identified differentiation conditions that generate HSCs defined by robust long-term multilineage engraftment in immune-deficient NOD,B6.PrkdcscidIl2rgtm1Wjl/SzJKitW41/W41 mice. We… read more here.
Keywords: multilineage; culture; stem cells; human induced ... See more keywords
High-fat diet intensifies MLL-AF9-induced acute myeloid leukemia through activation of the FLT3 signaling in mouse primitive hematopoietic cells
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-73020-4
Abstract: Using a MLL-AF9 knock-in mouse model, we discovered that consumption of a high-fat diet (HFD) accelerates the risk of developing acute myeloid leukemia (AML). This regimen increases the clusterization of FLT3 within lipid rafts on… read more here.
Keywords: fat diet; primitive hematopoietic; high fat; mll af9 ... See more keywords