Mechanisms of Tolerance Induction by Hematopoietic Chimerism: The Immune Perspective
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DOI: 10.1002/sctm.16-0358
Abstract: Hematopoietic chimerism is one of the effective approaches to induce tolerance to donor‐derived tissue and organ grafts without administration of life‐long immunosuppressive therapy. Although experimental efforts to develop such regimens have been ongoing for decades,… read more here.
Keywords: mechanisms tolerance; medicine; tolerance; hematopoietic chimerism ... See more keywords
SUCCESSFUL INDUCTION OF HEMATOPOIETIC CHIMERISM BY MCL-1 AND BCL-2 INHIBITION WITHOUT RADIATION/CHEMO THERAPY IN NONHUMAN PRIMATES
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DOI: 10.1097/01.tp.0000699448.79133.8d
Abstract: Allograft tolerance in clinical HLA mismatched kidney transplantation has been achieved by induction of hematopoietic chimerism via donor bone marrow transplantation (BMT). However, wider clinical application of tolerance regimens has been hampered by the myelosuppressive… read more here.
Keywords: mcl; abt 199; chimerism; hematopoietic chimerism ... See more keywords
Selective Bcl-2 inhibition promotes hematopoietic chimerism and allograft tolerance without myelosuppression in nonhuman primates
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DOI: 10.1126/scitranslmed.add5318
Abstract: Hematopoietic stem cell transplantation (HSCT) has many potential applications beyond current standard indications, including treatment of autoimmune disease, gene therapy, and transplant tolerance induction. However, severe myelosuppression and other toxicities after myeloablative conditioning regimens have… read more here.
Keywords: hematopoietic chimerism; inhibition; bcl; allograft tolerance ... See more keywords